Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Peiwei Wen, Li-Gang Cao, J. Margueron, H. Sagawa. Spin-isospin Response in Finite Nuclei from an Extended Skyrme Interaction. Physical Review C, 2014, 89, pp.044311. ⟨10.1103/PhysRevC.89.044311⟩. ⟨in2p3-00945610⟩
  • V. Khachatryan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Constraints on the Higgs boson width from off-shell production and decay to Z-boson pairs. Physics Letters B, 2014, 736, pp.64. ⟨10.1016/j.physletb.2014.06.077⟩. ⟨in2p3-00991252⟩
  • V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Double parton interactions in photon + 3 jet and photon + b/c jet + 2 jet events in ppbar collisions at sqrt{s}=1.96 TeV. Physical Review D, 2014, 89, pp.072006. ⟨10.1103/PhysRevD.89.072006⟩. ⟨in2p3-00943998⟩
  • T. Aaltonen, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Observation of s-channel production of single top quarks at the Tevatron. Physical Review Letters, 2014, 112, pp.231803. ⟨10.1103/PhysRevLett.112.231803⟩. ⟨in2p3-00951200⟩
  • V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Jet energy scale determination in the D0 experiment. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2014, 763, pp.442-475. ⟨10.1016/j.nima.2014.05.044⟩. ⟨in2p3-00923549⟩
  • T. Aaltonen, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Combination of measurements of the top-quark pair production cross section from the Tevatron Collider. Physical Review D, 2014, 89, pp.072001. ⟨10.1103/PhysRevD.89.072001⟩. ⟨in2p3-00868036⟩
  • V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Study of CP-violating charge asymmetries of single muons and like-sign dimuons in p pbar collisions. Physical Review D, 2014, 89, pp.012002. ⟨10.1103/PhysRevD.89.012002⟩. ⟨in2p3-00868829⟩
  • S. Chatrchyan, S. Baffioni, F. Beaudette, L. Benhabib, M. Bluj, et al.. Measurement of the triple-differential cross section for photon+jets production in proton-proton collisions at sqrt(s)=7 TeV. Journal of High Energy Physics, 2014, 6, pp.9. ⟨10.1007/JHEP06(2014)009⟩. ⟨in2p3-00909173⟩
  • S. Chatrchyan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for pair production of excited top quarks in the lepton+jets final state. Journal of High Energy Physics, 2014, 6, pp.125. ⟨10.1007/JHEP06(2014)125⟩. ⟨in2p3-00912494⟩
  • S. Chatrchyan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of higher-order harmonic azimuthal anisotropy in PbPb collisions at a nucleon-nucleon center-of-mass energy of 2.76 TeV. Physical Review C, 2014, 89, pp.044906. ⟨10.1103/PhysRevC.89.044906⟩. ⟨in2p3-00879540⟩

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