Health (PRISME)

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  • Activities
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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
546 documents

  • J.-B. Guy, S. Espenel, A. Vallard, B. Méry, C. Rancoule, et al.. Targeting Cancer Stem Cells in HNSCC: Synergic Effect of Cetuximab and ABT-199 in Combination with Photon Radiation. ASTRO Meeting, Sep 2017, San Diego, United States. 99 (2), 2017, International Journal of Radiation Oncology*Biology*Physics - Proceedings of the American Society for Radiation Oncology. ⟨10.1016/j.ijrobp.2017.06.2028⟩. ⟨hal-01610138⟩
  • A. Vallard, E. Bernichon, Q. Wang, Valéry Attignon, Daniel Pissaloux, et al.. Genomic Alterations and Radioresistance in Breast Cancer: An Analysis of the Profiler Protocol. ASTRO Meeting, Sep 2017, San Diego, United States. pp.S52, ⟨10.1016/j.ijrobp.2017.06.132⟩. ⟨hal-01610147⟩
  • Matthieu Giroux, Hamid Ladjal, Michael Beuve, Behzad Shariat Torbaghan. Biomechanical Patient-Specific Model of the Respiratory System Based on 4D CT Scans and Controlled by Personalized Physiological . Medical Image Computing and Computer Assisted Intervention - MICCAI 2017 - 20th International Conference, Sep 2017, Quebec, Canada. pp.216-223. ⟨hal-01589991⟩
  • J. Garcia, J. Forestier, E. Dusserre, C. Rodriguez-Lafrasse, V. Cheynet, et al.. Comparison of performances of three technologies for detection of RAS mutations in cfDNA (NGS strategy, BEAMing assay and ddPCR BioRAD assay). 42nd ESMO Congress (ESMO 2017), Sep 2017, Madrid (ES), Spain. pp.197, ⟨10.1093/annonc/mdx393.107⟩. ⟨hal-04499713⟩
  • E. Bernichon, A. Vallard, Qiang Wang, Valéry Attignon, Daniel Pissaloux, et al.. Genomic alterations and radioresistance in breast cancer: an analysis of the ProfiLER protocol.. Annals of Oncology, 2017, 28 (11), pp.2773-2779. ⟨10.1093/annonc/mdx488⟩. ⟨hal-01610114⟩
  • Anne-Sophie Wozny, Marie-Thérèse Aloy, Gersende Alphonse, Nicolas Magné, Marc Janier, et al.. Gadolinium-based nanoparticles as sensitizing agents to carbon ions in head and neck tumor cells. Nanomedicine: Nanotechnology, Biology and Medicine, 2017, 13 (8), pp.2655-2660. ⟨10.1016/j.nano.2017.07.015⟩. ⟨hal-01610099⟩
  • Nils Krah, L. de Marzi, Annalisa Patriarca, G. Pitta, Ilaria Rinaldi. High Resolution Proton Radiography Using Sophisticated Image Processing Methods and a Commercial Plug and Play Detector. AAPM 59th Annual Meeting and Exhibition, Jul 2017, Denver, United States. ⟨hal-01795464⟩
  • J. Collot, A. Bes, G. Bosson, S. Curtoni, D. Dauvergne, et al.. Production and characterization of large-size diamond detectors for particle tracking and medical applications. European Physical Society Conference on High Energy Physics (EPS-HEP2017), Jul 2017, Venice, Italy. pp.781. ⟨hal-01680951⟩
  • Floriane Poignant, Benoit Gervais, Andrei Ipatov, Caterina Monini, Micaela Cunha, et al.. Biophysical modelisation of gold nanoparticles radiosensi-tizing effects. Nanotech France 2017, Jun 2017, Paris, France. ⟨hal-01622298⟩
  • Claire Rodriguez-Lafrasse. Differential superiority of carbon ion irradiation and radiosensitizing nanoparticles to X-Rays: studies on biological effectiveness in tumor cell models . OIST Invited Conference, Jun 2017, Okinawa, Japan. ⟨hal-01609994⟩

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