Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
476 documents

  • Claire Rodriguez-Lafrasse, Coralie Moncharmont, Priscillia Battiston-Montagne, Ghassan Hamdan, Anne Wozny, et al.. Cancer Stem Cells and EMT: Guilty of HNSCC Recurrences but Condemned by the Combination of Carbon Ion Irradiation and EGFR inhibition. 15th International Congress of Radiation Research - ICCR 2015, May 2015, Kyoto, Japan. ⟨hal-01228733⟩
  • Gersende Alphonse, Sylvain Ferrandon, Priscillia Battiston-Montagne, Julie Constanzo, Delphine Poncet, et al.. Cellular and molecular portrait of eleven human glioblastoma cell lines irradiated with photons or carbon ions. Space Radiation and Heavy Ions in Therapy Symposium 2015　（SRHITS 2015), May 2015, Osaka, Japan. ⟨hal-01228749⟩
  • G. Alphonse, Coralie Moncharmont, A. Wozny, S. Simonet, P. Battiston-Montagne, et al.. Why carbon ions better cure radioresistant cancers: the cellular and molecular visions of the radiobiologist. Space Radiation and Heavy Ions in Therapy Symposium 2015　（SRHITS 2015), May 2015, Osaka, Japan. ⟨hal-01236081⟩
  • M. Beuve, M. Cunha, C. Monini, E. Testa. From water radiolysis to hadrontherapy: NanoxTM a multi-scale model for biological effects. Swift Heavy Ions in Matter (SHIM) 2015, May 2015, Darmstad, Germany. ⟨hal-01206693⟩
  • N. Arbor, D. Dauvergne, G. Dedes, Jean Michel Létang, K. Parodi, et al.. Monte Carlo evaluation of X-ray and proton CT for the prediction of the range of proton therapy beams. 3rd ESTRO Forum 2015, Apr 2015, Barcelona, Spain. p87 PD-0139. ⟨hal-01279593⟩
  • Jochen Krimmer, L. Balleyguier, Denis Dauvergne, Hervé Mathez, Marco Pinto, et al.. Prompt-gamma detection towards absorbed energy monitoring during hadrontherapy. ANIMMA 2015: International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, Apr 2015, Lisboa, Portugal. ⟨hal-02064149⟩
  • D Dauvergne, J. Baudot, N. Freud, J. Krimmer, L. Lestand, et al.. Online control of the beam range during Hadrontherapy. Forum de la recherche en cancérologie Rhône-Alpes Auvergne, Apr 2015, Lyon, France. ⟨hal-01241411⟩
  • Gersende Alphonse, Clément Bernard, Julie Constanzo, Denis Dauvergne, Michael Beuve, et al.. Radiological studies with low energy protons at the Radiograaff Platform. Forum de la recherche en cancérologie Rhône-Alpes Auvergne, Apr 2015, Lyon, France. ⟨hal-01236101⟩
  • G. Alphonse, A. Wozny, G. Bertrand, P. Battiston-Montagne, M. Beuve, et al.. Overcoming resistance to irradiation of Head and Neck Squamous Cell Carcinoma by targeting the cancer stem cell subpopulation. Forum de la recherche en cancérologie Rhône-Alpes Auvergne, Apr 2015, Lyon, France. ⟨hal-01235809⟩
  • Joseph Remillieux, Jean-Michel Moreau, Denis Dauvergne, Jacques Balosso. Les enjeux de l’hadronthérapie par ions carbone. Reflets de la Physique, 2015, 43, pp.26-30. ⟨10.1051/refdp/201543026⟩. ⟨hal-01180095⟩

Powered by HAL logo