Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- B. Abelev, Laurent Aphecetche, A. Baldisseri, V. Barret, N. Bastid, et al.. Multi-strange baryon production at mid-rapidity in Pb-Pb collisions at sqrt(s_NN) = 2.76 TeV. Physics Letters B, 2014, 728, pp.216-227. ⟨10.1016/j.physletb.2013.11.048⟩. ⟨in2p3-00847195⟩
- N. Agafonova, D. Autiero, L. Chaussard, P. del Amo Sanchez, M. Dracos, et al.. Erratum: New results on
appearance with the OPERA experiment in the CNGS beam. Journal of High Energy Physics, 2014, 2014(04), pp.14. ⟨10.1007/JHEP04(2014)014⟩. ⟨in2p3-00854495⟩ - Sophie Rihs, Clotilde Gaillard, Tobias Reich, Stephan Kohler. Uranyl sorption onto birnessite: A surface complexation modeling and EXAFS study. Chemical Geology, 2014, 373, pp.59-70. ⟨10.1016/j.chemgeo.2014.02.025⟩. ⟨in2p3-00980434⟩
- S. Chatrchyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the W gamma and Z gamma inclusive cross sections in pp collisions at sqrt(s) = 7 TeV and limits on anomalous triple gauge boson couplings. Physical Review D, 2014, 89, pp.092005. ⟨10.1103/PhysRevD.89.092005⟩. ⟨in2p3-00856608⟩
- S. Chatrchyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of associated W + charm production in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2014, 02(2014), pp.013. ⟨10.1007/JHEP02(2014)013⟩. ⟨in2p3-00873026⟩
- S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for stop and higgsino production using diphoton Higgs boson decays. Physical Review Letters, 2014, 112, pp.161802. ⟨10.1103/PhysRevLett.112.161802⟩. ⟨in2p3-00917556⟩
- S. Chatrchyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for the standard model Higgs boson produced in association with a W or a Z boson and decaying to bottom quarks. Physical Review D, 2014, 89, pp.012003. ⟨10.1103/PhysRevD.89.012003⟩. ⟨in2p3-00873020⟩
- S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Evidence for the 125 GeV Higgs boson decaying to a pair of tau leptons. Journal of High Energy Physics, 2014, 5, pp.104. ⟨10.1007/JHEP05(2014)104⟩. ⟨in2p3-00934001⟩
- S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Alignment of the CMS tracker with LHC and cosmic ray data. Journal of Instrumentation, 2014, 9, pp.P06009. ⟨10.1088/1748-0221/9/06/P06009⟩. ⟨in2p3-00957751⟩
- S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for top-quark partners with charge 5/3 in the same-sign dilepton final state. Physical Review Letters, 2014, 112, pp.1801. ⟨10.1103/PhysRevLett.112.171801⟩. ⟨in2p3-00916272⟩
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