Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • R. Chierici. Top quark physics at the LHC. Rivista del Nuovo Cimento, 2014, 37, pp.47-123. ⟨10.1393/ncr/i2014-10097-2⟩. ⟨in2p3-00999735⟩
  • K. Maguire, M. Sullivan, Y.-C. Pan, A. Gal-Yam, I.M. Hook, et al.. Exploring the spectral diversity of low-redshift Type Ia supernovae using the Palomar Transient Factory. Monthly Notices of the Royal Astronomical Society, 2014, 444, pp.3258-3274. ⟨10.1093/mnras/stu1607⟩. ⟨in2p3-01134718⟩
  • M. Kibler. ÉlĂ©ments d’analyse et de calcul matriciel Ă  l’usage des Ă©tudiants en sciences physiques. 2014, 9782340000070. ⟨in2p3-01581043⟩
  • H. Abdoul-Carime, F. Berthias, B. Farizon, M. Farizon. Correlated detection of neutral and charged fragments in collision induced fragmentation of molecular clusters. International Journal of Mass Spectrometry, 2014, 365-366, pp.311-315. ⟨10.1016/j.ijms.2014.01.009⟩. ⟨in2p3-00932145⟩
  • G. Dedes, M. Pinto, D. Dauvergne, N. Freud, J. Krimmer, et al.. Assessment and improvements of Geant4 hadronic models in the context of prompt-gamma hadrontherapy monitoring. Physics in Medicine and Biology, 2014, 59 (7), pp.1747-1772. ⟨10.1088/0031-9155/59/7/1747⟩. ⟨hal-00967197⟩
  • V.M. Abazov, M. Arthaud, F. Badaud, U. Bassler, M. Besançon, et al.. Muon reconstruction and identification with the Run II D0 detector. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2014, 737, pp.281-294. ⟨10.1016/j.nima.2013.11.050⟩. ⟨in2p3-00846843⟩
  • V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Measurement of the forward-backward asymmetry in top quark-antiquark production in ppbar collisions using the lepton+jets channel. Physical Review D, 2014, 90, pp.072011. ⟨10.1103/PhysRevD.90.072011⟩. ⟨in2p3-00987045⟩
  • V.M. Abazov, F. Badaud, U. Bassler, M. Besançon, D. Brown, et al.. Search for the X(4140) state in B+->J/psi phi K+ decays with the D0 detector. Physical Review D, 2014, 89, pp.012004. ⟨10.1103/PhysRevD.89.012004⟩. ⟨in2p3-00866106⟩
  • S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Alignment of the CMS tracker with LHC and cosmic ray data. Journal of Instrumentation, 2014, 9, pp.P06009. ⟨10.1088/1748-0221/9/06/P06009⟩. ⟨in2p3-00957751⟩
  • S. Chatrchyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the W gamma and Z gamma inclusive cross sections in pp collisions at sqrt(s) = 7 TeV and limits on anomalous triple gauge boson couplings. Physical Review D, 2014, 89, pp.092005. ⟨10.1103/PhysRevD.89.092005⟩. ⟨in2p3-00856608⟩

Powered by HAL logo