Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Laurent Aphecetche, Y.W. Baek, V. Barret, N. Bastid, Guillaume Batigne, et al.. Production of charged pions, kaons and protons at large transverse momenta in pp and Pb-Pb collisions at sqrt(sNN) = 2.76 TeV. Physics Letters B, 2014, 736, pp.196-207. ⟨10.1016/j.physletb.2014.07.011⟩. ⟨in2p3-00925441⟩
  • S. Chatrchyan, S. Baffioni, F. Beaudette, L. Benhabib, M. Bluj, et al.. Measurement of the production cross section for a W boson and two b jets in pp collisions at sqrt(s) = 7 TeV. Physics Letters B, 2014, 735, pp.204-225. ⟨10.1016/j.physletb.2014.06.041⟩. ⟨in2p3-00925482⟩
  • F. Berthias, L. Feketeova, H. Abdoul-Carime, B. Farizon, M. Farizon. Correlation ion and neutral time of flight mass spectrometry. 3rd Annual Conference and EXPO of Analytix 2014, 2014, Dailan, China. ⟨in2p3-01009144⟩
  • K. Bennaceur. Finite-range effective interaction for mean-field calculation and beyond. LEA Colliga and LEA Copigal Workshop - French-Italian and French-Polish, 2014, Paris, France. ⟨in2p3-00973416⟩
  • D. Tsimpis. IIA/M-theory on eightmanifolds revisited. Recent Developments in Supergravity Theories, 2014, Istanbul, Turkey. ⟨in2p3-01019705⟩
  • G. Angloher, E. Armengaud, C. Augier, A. Benoit, T. Bergmann, et al.. EURECA Conceptual Design Report. Physics of the Dark Universe, 2014, 3, pp.41-74. ⟨10.1016/j.dark.2014.03.004⟩. ⟨in2p3-01017291⟩
  • K. Abe, J. Adam, H. Aihara, T. Akiri, C. Andreopoulos, et al.. Precise Measurement of the Neutrino Mixing Parameter \theta_{23} from Muon Neutrino Disappearance in an Off-axis Beam. Physical Review Letters, 2014, 112, pp.181801. ⟨10.1103/PhysRevLett.112.181801⟩. ⟨in2p3-00956637⟩
  • K. Abe, J. Adam, H. Aihara, T. Akiri, C. Andreopoulos, et al.. Observation of Electron Neutrino Appearance in a Muon Neutrino Beam. Physical Review Letters, 2014, 112, pp.061802. ⟨10.1103/PhysRevLett.112.061802⟩. ⟨in2p3-00912454⟩
  • F. Berthias, H. Abdoul-Carime, L. Feketeovà, R. Filliol, B. Farizon, et al.. Charge-Transfer Induced Dissociation in the H+(H2O)3-Ar collisions observed with the COINTOF mass spectrometer. The European Physical Journal D : Atomic, molecular, optical and plasma physics, 2014, 68, pp.148. ⟨10.1140/epjd/e2014-40833-0⟩. ⟨in2p3-01003196⟩
  • V.M. Abazov, M.-C. Cousinou, A. Duperrin, W. Geng, E. Kajfasz, et al.. Constraints on models for the Higgs boson with exotic spin and parity in VH→Vbb¯ final states. Physical Review Letters, 2014, 113, pp.161802. ⟨10.1103/PhysRevLett.113.161802⟩. ⟨in2p3-01048562⟩

Powered by HAL logo