The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Searches for electroweak production of charginos, neutralinos, and sleptons decaying to leptons and W, Z, and Higgs bosons in pp collisions at 8 TeV. European Physical Journal C: Particles and Fields, 2014, 74, pp.3036. ⟨10.1140/epjc/s10052-014-3036-7⟩. ⟨in2p3-01226388⟩
- V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Electron and Photon Identification in the D0 Experiment. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2014, 750, pp.78-95. ⟨10.1016/j.nima.2014.03.013⟩. ⟨in2p3-00923932⟩
- V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Study of hadronic event-shape variables in multijet final states in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2014, 10(2014), pp.087. ⟨10.1007/JHEP10(2014)087⟩. ⟨in2p3-01134730⟩
- S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for anomalous production of events with three or more leptons in pp collisions at sqrt(s)=8 TeV. Physical Review D, 2014, 90, pp.032006. ⟨10.1103/PhysRevD.90.032006⟩. ⟨in2p3-00982499⟩
- S. Chatrchyan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the muon charge asymmetry in inclusive pp to WX production at sqrt(s)=7 TeV and an improved determination of light parton distribution functions. Physical Review D, 2014, 90, pp.032004. ⟨10.1103/PhysRevD.90.032004⟩. ⟨in2p3-00924271⟩
- S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Measurement of WZ and ZZ production in pp collisions at sqrt(s) = 8 TeV in final states with b-tagged jets. European Physical Journal C: Particles and Fields, 2014, 74, pp.2973. ⟨10.1140/epjc/s10052-014-2973-5⟩. ⟨in2p3-00958619⟩
- S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Event activity dependence of Y(nS) production in sqrt(s[NN])=5.02 TeV pPb and sqrt(s)=2.76 TeV pp collisions. Journal of High Energy Physics, 2014, 4, pp.103. ⟨10.1007/JHEP04(2014)103⟩. ⟨in2p3-00925493⟩
- B. Abelev, Laurent Aphecetche, Y.W. Baek, V. Barret, N. Bastid, et al.. Measurement of charged jet suppression n Pb-Pb collisions at sqrt(sNN)=2.76TeV. Journal of High Energy Physics, 2014, 3, pp.013. ⟨10.1007/JHEP03(2014)013⟩. ⟨in2p3-00879847⟩
- S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Description and performance of track and primary-vertex reconstruction with the CMS tracker. Journal of Instrumentation, 2014, 9, pp.P10009. ⟨10.1088/1748-0221/9/10/P10009⟩. ⟨in2p3-00996805⟩
- V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for the associated production of the Higgs boson with a top-quark pair. Journal of High Energy Physics, 2014, 09, pp.087. ⟨10.1007/JHEP09(2014)087⟩. ⟨in2p3-01056249⟩