Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- A. Valassi, R. Chierici. Information and treatment of unknown correlations in the combination of measurements using the BLUE method. European Physical Journal C: Particles and Fields, 2014, 74, pp.2717. ⟨10.1140/epjc/s10052-014-2717-6⟩. ⟨in2p3-00845552⟩
- Teng Ma, Bin Zhang, G. Cacciapaglia. Triplet with a doubly-charged lepton at the LHC. Physical Review D, 2014, 89, pp.015020. ⟨10.1103/PhysRevD.89.015020⟩. ⟨in2p3-00904263⟩
- K. Bennaceur. New effective forces for mean-field and beyond mean-field calculations. 2nd Topical Workshop on Modern Aspects in Nuclear Structure, 2014, Bormio, Italy. ⟨in2p3-00973414⟩
- Q. Arnaud. Signals Induced by Charge Carrier Trapping. Journal of Low Temperature Physics, 2014, 176, pp.924-929. ⟨10.1007/s10909-014-1106-8⟩. ⟨in2p3-01066225⟩
- J. J. Li, W. H. Long, J. Margueron, N. van Giai. Superheavy magic structures and relativistic pseudo-spin symmetry. Physics Letters B, 2014, 732, pp.169-173. ⟨10.1016/j.physletb.2014.03.031⟩. ⟨in2p3-00838514⟩
- A Sabau, Y Pipon, N Toulhoat, C Lomenech, N Jordan, et al.. Interaction of europium and nickel with calcite studied by Rutherford Backscattering Spectrometry and Time-Resolved Laser Fluorescence Spectroscopy. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2014, ⟨10.1016/j.nimb.2014.02.041⟩. ⟨hal-01306310⟩
- B. Abelev, Laurent Aphecetche, V. Barret, N. Bastid, Guillaume Batigne, et al.. Performance of the ALICE Experiment at the CERN LHC. International Journal of Modern Physics A, 2014, 29, pp.1430044. ⟨10.1142/S0217751X14300440⟩. ⟨in2p3-00949658⟩
- Vardan Khachatryan, Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, et al.. Search for jet extinction in the inclusive jet-
spectrum from proton-proton collisions at 
8 TeV. Physical Review D, 2014, 90 (3), pp.032005. ⟨10.1103/PhysRevD.90.032005⟩. ⟨hal-02101750⟩ - B. Abelev, Laurent Aphecetche, Y.W. Baek, V. Barret, N. Bastid, et al.. Two and Three-Pion Quantum Statistics Correlations in Pb-Pb Collisions at sqrt(sNN)=2.76 TeV at the LHC. Physical Review C, 2014, 89, pp.024911. ⟨10.1103/PhysRevC.89.024911⟩. ⟨in2p3-00878401⟩
- V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Measurement of the Electric Charge of the Top Quark in
Events. Physical Review D, 2014, 90, pp.051101(R). ⟨10.1103/PhysRevD.90.051101⟩. ⟨in2p3-01026175⟩
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