Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, M.-C. Cousinou, A. Duperrin, W. Geng, E. Kajfasz, et al.. Measurement of the direct CP-violating parameter A_CP in the decay D+ -> K- pi+ pi+. Physical Review D, 2014, 90, pp.111102(R). ⟨10.1103/PhysRevD.90.111102⟩. ⟨in2p3-01059451⟩
  • J. Zmuda, M. Zito, E. D. Zimmerman, M. Ziembicki, K. Zaremba, et al.. Measurement of the intrinsic electron neutrino component in the T2K neutrino beam with the ND280 detector. Physical Review D, 2014, 89, pp.092003. ⟨10.1103/PhysRevD.89.092003⟩. ⟨in2p3-00958221⟩
  • L. Agostino, B. Andrieu, R. Asfandiyarov, D. Autiero, O. BĂ©sida, et al.. LBNO-DEMO: Large-scale neutrino detector demonstrators for phased performance assessment in view of a long-baseline oscillation experiment. [Research Report] CERN. 2014. ⟨in2p3-01229977⟩
  • K. Abe, J. Adam, H. Aihara, T. Akiri, C. Andreopoulos, et al.. Measurement of the neutrino-oxygen neutral-current interaction cross section by observing nuclear de-excitation \gamma-rays. Physical Review D, 2014, 90 (7), pp.072012. ⟨10.1103/PhysRevD.90.072012⟩. ⟨in2p3-00962301⟩
  • V. Khachatryan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for heavy neutrinos and W bosons with right-handed couplings in proton-proton collisions at sqrt(s) = 8 TeV. European Physical Journal C: Particles and Fields, 2014, 74, pp.3149. ⟨10.1140/epjc/s10052-014-3149-z⟩. ⟨in2p3-01023625⟩
  • V. Khachatryan, S. Viret, F. Couderc, H. Xiao, M. Dejardin, et al.. Searches for heavy Higgs bosons in two-Higgs-doublet models and for t→ch decay using multilepton and diphoton final states in pp collisions at 8 TeV. Physical Review D, 2014, 90, pp.112013. ⟨10.1103/PhysRevD.90.112013⟩. ⟨in2p3-01074944⟩
  • G. Brooijmans, R. Contino, B. Fuks, F. Moortgat, P. Richardson, et al.. Les Houches 2013: Physics at TeV Colliders: New Physics Working Group Report. 201 p., 2014, Proceedings of the New Physics Working Group of the 2013 Les Houches Workshop, Physics at TeV Colliders. ⟨hal-00988570⟩
  • V. Khachatryan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Measurement of prompt J/psi pair production in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2014, 09(2014), pp.094. ⟨10.1007/JHEP09(2014)094⟩. ⟨in2p3-00998920⟩
  • V. Khachatryan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for massive resonances decaying into pairs of boosted bosons in semi-leptonic final states at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2014, 1408, pp.174. ⟨10.1007/JHEP08(2014)174⟩. ⟨in2p3-00991250⟩
  • S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for supersymmetry with razor variables in pp collisions at sqrt(s)=7 TeV. Physical Review D, 2014, 90, pp.112001. ⟨10.1103/PhysRevD.90.112001⟩. ⟨in2p3-00991793⟩

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