Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
546 documents

  • Jean-Baptiste Guy, Benoîte Méry, Edouard Ollier, Sophie Espenel, Alexis Vallard, et al.. Dual “mAb” HER family blockade in head and neck cancer human cell lines combined with photon therapy. Scientific Reports, 2017, 7 (1), pp.12207 - 12207. ⟨10.1038/s41598-017-12367-7⟩. ⟨hal-01609975⟩
  • Chloé Rancoule, Alexis Vallard, Jean-Baptiste Guy, Sophie Espenel, Sylvie Sauvaigo, et al.. Altération de la réparation de l’ADN et cancer. Bulletin du Cancer, 2017, 104 (11), pp.962 - 970. ⟨10.1016/j.bulcan.2017.09.006⟩. ⟨hal-01690785⟩
  • Jc Trone, S. Espenel, A. Rehailia-Blanchard, E. Guillaume, N. Vial, et al.. Navigating the highlights of phase III trials: a watchful eye on evidence-based radiotherapy. Annals of Oncology, 2017, 28 (11), pp.2691 - 2697. ⟨10.1093/annonc/mdx347⟩. ⟨hal-01690827⟩
  • Alexis Vallard, Chloé Rancoule, Jean-Baptiste Guy, Sophie Espenel, Sylvie Sauvaigo, et al.. Biomarkers of radiation-induced DNA repair processes. Bulletin du Cancer, 2017, 104 (11), pp.981 - 987. ⟨10.1016/j.bulcan.2017.09.004⟩. ⟨hal-01690794⟩
  • Mattia Fontana, Denis Dauvergne, Jochen Krimmer, Jean Michel Létang, Jean-Luc Ley, et al.. Comparison between Anger and Compton cameras for medical imaging: a Monte Carlo simulation study. 2017 IEEE NSS/MIC/RTSD, Oct 2017, Atlanta, United States. 2017. ⟨hal-01609932⟩
  • Anne-Sophie Wozny, Gersende Alphonse, Yannick Saintigny, Michaël Beuve, Claire Rodriguez-Lafrasse. A major contribution of the HIF-1α pathway in the oxygen effect. 63rd annual international meeting of Radiation Reaserach Society, Oct 2017, Cancun, Mexico. 2017. ⟨hal-01610972⟩
  • Claire Rodriguez-Lafrasse, Marie-Thérèse Aloy, Jacqueline Sidi Boumedine, Shady Kotb, Lucie Sancey, et al.. AGuIX radiosensitizing nanoparticles: from molecular events to clinical applications. 63rd annual international meeting of Radiation Reaserach Society, Oct 2017, Cancun, Mexico. ⟨hal-01610963⟩
  • Floriane Poignant, Benoit Gervais, Andrei Ipatov, Caterina Monini, Micaela Cunha, et al.. Biophysical modelisation of gold nanoparticles radiosensitizing effects. International Conference on Monte Carlo Techniques for Medical Applications (MCMA2017), Oct 2017, Napoli, Italy. pp.38-39, ⟨10.1016/j.ejmp.2017.09.094⟩. ⟨hal-01620547⟩
  • Sophie Espenel, Jean-Baptiste Guy, Anne-Sophie Wozny, Priscillia Battiston-Montagne, Chloé Rancoule, et al.. Evaluation préclinique en modèle 3D de l’association de l’ABT-199 au cetuximab et aux radiations ionisantes sur les cellules cancéreuses ORL. SFRO 17, Oct 2017, Paris, France. ⟨hal-02062295⟩
  • Veronica Tessaro, Mariel E. Galassi, Benoit Gervais, Michael Beuve. Evaluación de la contribucion de electrones Auger y efectos relativistas en la determinación de valores-w por impacto de electrones. 102a Reunión Nacional de Física - Asociación Física Argentina, Sep 2017, Buenos Aires, Argentina. ⟨hal-02050659⟩

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