Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for new neutral Higgs bosons through the H\to ZA \to \ell^{+}\ell^{-} \mathrm{b\bar{b}} process in pp collisions at \sqrt{s} = 13 TeV. JHEP, 2020, 03, pp.055. ⟨10.1007/JHEP03(2020)055⟩. ⟨hal-02392984⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Observation of the B^0_\mathrm{s}\toX(3872)\phi decay. Phys.Rev.Lett., 2020, 125 (15), pp.152001. ⟨10.1103/PhysRevLett.125.152001⟩. ⟨hal-02628106⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. A search for bottom-type, vector-like quark pair production in a fully hadronic final state in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Rev.D, 2020, 102, pp.112004. ⟨10.1103/PhysRevD.102.112004⟩. ⟨hal-02940013⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of differential cross sections and charge ratios for t-channel single top quark production in proton–proton collisions at \sqrt{s}=13\,\text {Te}\text {V}. Eur.Phys.J.C, 2020, 80 (5), pp.370. ⟨10.1140/epjc/s10052-020-7858-1⟩. ⟨hal-02277915⟩
  • Alexandre Arbey, Jérémy Auffinger, Joseph Silk. Constraining primordial black hole masses with the isotropic gamma ray background. Physical Review D, 2020, 101 (2), pp.023010. ⟨10.1103/PhysRevD.101.023010⟩. ⟨hal-02165521⟩
  • Aurelien Carle, Nicolas Chanon, Stephane Perries. Prospects for Lorentz Invariance Violation searches with top pair production at the LHC and future hadron colliders. European Physical Journal C: Particles and Fields, 2020, 80 (2), pp.128. ⟨10.1140/epjc/s10052-020-7715-2⟩. ⟨hal-02309061⟩
  • Philippe Baratta, Julien Bel, Stephane Plaszczynski, Anne Ealet. High-precision Monte-Carlo modelling of galaxy distribution. Astronomy & Astrophysics - A&A, 2020, 633, pp.A26. ⟨10.1051/0004-6361/201936163⟩. ⟨hal-02188898⟩
  • Peng Wang, Xi Kang, Noam I. Libeskind, Quan Guo, Stefan Gottlöber, et al.. A robust determination of halo environment in the cosmic field. New Astron., 2020, 80, pp.101405. ⟨10.1016/j.newast.2020.101405⟩. ⟨hal-02870813⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of single-diffractive dijet production in proton-proton collisions at \sqrt{s} = 8 TeV with the CMS and TOTEM experiments. European Physical Journal C: Particles and Fields, 2020, 80 (12), pp.1164. ⟨10.1140/epjc/s10052-020-08562-y⟩. ⟨hal-02507664⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Strange hadron production in pp and pPb collisions at \sqrt{s_\mathrm{NN}}= 5.02 TeV. Physical Review C, 2020, 101 (6), pp.064906. ⟨10.1103/PhysRevC.101.064906⟩. ⟨hal-02403770⟩

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