Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V. Khachatryan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Measurement of prompt J/psi pair production in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2014, 09(2014), pp.094. ⟨10.1007/JHEP09(2014)094⟩. ⟨in2p3-00998920⟩
  • V. Khachatryan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for massive resonances decaying into pairs of boosted bosons in semi-leptonic final states at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2014, 1408, pp.174. ⟨10.1007/JHEP08(2014)174⟩. ⟨in2p3-00991250⟩
  • S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for supersymmetry with razor variables in pp collisions at sqrt(s)=7 TeV. Physical Review D, 2014, 90, pp.112001. ⟨10.1103/PhysRevD.90.112001⟩. ⟨in2p3-00991793⟩
  • A. Astier, M.G. Porquet, T. Venkova, C. Theisen, G. Duchene, et al.. High-spin structures of 124−131Te: Competition of proton- and neutron-pair breakings. The European physical journal. A, Hadrons and Nuclei, 2014, 50, pp.2. ⟨10.1140/epja/i2014-14002-5⟩. ⟨hal-01108842⟩
  • M.-A. Chanrion, W. Sauerwein, U. Jelen, A. Wittig, R. Engenhart-Cabillic, et al.. The influence of the local effect model parameters on the prediction of the tumor control probability for prostate cancer. Physics in Medicine and Biology, 2014, 59, pp.3019-3040. ⟨10.1088/0031-9155/59/12/3019⟩. ⟨hal-00990873⟩
  • S. Chatrchyan, S. Baffioni, F. Beaudette, L. Benhabib, M. Bluj, et al.. Search for supersymmetry in pp collisions at sqrt(s) = 8 TeV in events with a single lepton, large jet multiplicity, and multiple b jets. Physics Letters B, 2014, 733, pp.328-353. ⟨10.1016/j.physletb.2014.04.023⟩. ⟨in2p3-00907156⟩
  • B. Abelev, Laurent Aphecetche, Guillaume Batigne, I. Belikov, C. Cheshkov, et al.. Beauty production in pp collisions at \sqrt{s} = 2.76 TeV measured via semi-electronic decays. Physics Letters B, 2014, 738, pp.97-108. ⟨10.1016/j.physletb.2014.09.026⟩. ⟨in2p3-00992581⟩
  • B. Abelev, G. Conesa Balbastre, J. Faivre, C. Furget, R. Guernane, et al.. Azimuthal anisotropy of D meson production in Pb-Pb collisions at sqrt(sNN) = 2.76 TeV. Physical Review C, 2014, 90, pp.034904. ⟨10.1103/PhysRevC.90.034904⟩. ⟨in2p3-00988742⟩
  • A. G. Kim, G. Aldering, P. Antilogus, C. Aragon, S. Bailey, et al.. Type Ia Supernova Hubble Residuals and Host-Galaxy Properties. The Astrophysical Journal, 2014, 784, pp.51. ⟨10.1088/0004-637X/784/1/51⟩. ⟨in2p3-00935372⟩
  • J. Sorce, H. Courtois, Stefan Gottloeber, Yehuda Hoffman, R. Brent Tully. Simulations of the Local Universe Constrained by Observational Peculiar Velocities. Monthly Notices of the Royal Astronomical Society, 2014, 437, pp.3586-3595. ⟨10.1093/mnras/stt2153⟩. ⟨in2p3-00935377⟩

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