Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- D. Davesne, A. Pastore, J. Navarro. Linear response theory in asymmetric nuclear matter for Skyrme functionals including spin-orbit and tensor terms. Physical Review C, 2014, 89, pp.044302. ⟨10.1103/PhysRevC.89.044302⟩. ⟨in2p3-00949026⟩
- A. Valassi, R. Chierici. Information and treatment of unknown correlations in the combination of measurements using the BLUE method. European Physical Journal C: Particles and Fields, 2014, 74, pp.2717. ⟨10.1140/epjc/s10052-014-2717-6⟩. ⟨in2p3-00845552⟩
- Teng Ma, Bin Zhang, G. Cacciapaglia. Triplet with a doubly-charged lepton at the LHC. Physical Review D, 2014, 89, pp.015020. ⟨10.1103/PhysRevD.89.015020⟩. ⟨in2p3-00904263⟩
- K. Bennaceur. New effective forces for mean-field and beyond mean-field calculations. 2nd Topical Workshop on Modern Aspects in Nuclear Structure, 2014, Bormio, Italy. ⟨in2p3-00973414⟩
- Q. Arnaud. Signals Induced by Charge Carrier Trapping. Journal of Low Temperature Physics, 2014, 176, pp.924-929. ⟨10.1007/s10909-014-1106-8⟩. ⟨in2p3-01066225⟩
- Thierry Maciaszek, Anne Ealet, Knud Jahnke, Eric Prieto, Rémi Barbier, et al.. Euclid near infrared spectrophotometer instrument concept and first test results at the end of phase B. Proc.SPIE Int.Soc.Opt.Eng., 2014, 9143, ⟨10.1117/12.2056702⟩. ⟨hal-02097419⟩
- Nan Chen, Ying Zhang, Qing Wang, Giacomo Cacciapaglia, Aldo Deandrea, et al.. Higgsphobic and fermiophobic Z' as a single dark matter candidate. Journal of High Energy Physics, 2014, 05, pp.088. ⟨10.1007/JHEP05(2014)088⟩. ⟨in2p3-00958645⟩
- A. Pastore, M. Martini, D. Davesne, J. Navarro, S. Goriely, et al.. Linear response theory and neutrino mean free path using Brussels-Montreal Skyrme functionals. Physical Review C, 2014, 90, pp.025804. ⟨10.1103/PhysRevC.90.025804⟩. ⟨in2p3-01066816⟩
- D. Zaritsky, H. Courtois, J.-C. Muñoz-Mateos, J. Sorce, S. Erroz-Ferrer, et al.. The Baryonic Tully-Fisher Relationship for S
G Galaxies and the "Condensed" Baryon Fraction of Galaxies. The Astronomical Journal, 2014, 147, pp.134. ⟨10.1088/0004-6256/147/6/134⟩. ⟨in2p3-00958651⟩ - J.G. Sorce, R. B. Tully, H.M. Courtois, T. H. Jarrett, J. D. Neill, et al.. From Spitzer Galaxy photometry to Tully-Fisher distances. Monthly Notices of the Royal Astronomical Society, 2014, 444, pp.527-541. ⟨10.1093/mnras/stu1450⟩. ⟨in2p3-01066038⟩
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