Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Gauthier, R. Roy, P. St-Onge, B. Wallace, M.F. Rivet, et al.. Quasiprojectile and intermediate velocity isotopic ratios for light fragments emitted in the Ar 36 +Ni 58 and Ni 58 +Ni 58 reactions between 32A and 84A MeV. Physical Review C, 2014, 90, pp.034618. ⟨10.1103/PhysRevC.90.034618⟩. ⟨in2p3-01067158⟩
  • R. Scalzo, G. Aldering, P. Antilogus, C. Aragon, S. Bailey, et al.. Type Ia supernova bolometric light curves and ejected mass estimates from the Nearby Supernova Factory. Monthly Notices of the Royal Astronomical Society, 2014, 440, pp.1498-1518. ⟨10.1093/mnras/stu350⟩. ⟨in2p3-00958452⟩
  • S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Study of double parton scattering using W + 2-jet events in proton-proton collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2014, 03, pp.032. ⟨10.1007/JHEP03(2014)032⟩. ⟨in2p3-00921191⟩
  • S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for flavor-changing neutral currents in top-quark decays t to Zq in pp collisions at sqrt(s)=8 TeV. Physical Review Letters, 2014, 112, pp.171802. ⟨10.1103/PhysRevLett.112.171802⟩. ⟨in2p3-00919538⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of prompt psi(2S) to J/psi yield ratios in PbPb and pp collisions at sqrt(s[NN]) = 2.76 TeV. Physical Review Letters, 2014, 113, pp.262301. ⟨10.1103/PhysRevLett.113.262301⟩. ⟨in2p3-01073627⟩
  • B. Abelev, Laurent Aphecetche, Y.W. Baek, N. Bastid, Guillaume Batigne, et al.. Centrality, rapidity and transverse momentum dependence of J/Psi suppression in Pb-Pb collisions at sqrt(sNN)=2.76TeV. Physics Letters B, 2014, 734, pp.314-327. ⟨10.1016/j.physletb.2014.05.064⟩. ⟨in2p3-00879452⟩
  • S. Chatrchyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of differential cross sections for the production of a pair of isolated photons in pp collisions at sqrt(s) = 7 TeV. European Physical Journal C: Particles and Fields, 2014, 74, pp.3129. ⟨10.1140/epjc/s10052-014-3129-3⟩. ⟨in2p3-01110956⟩
  • S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Measurement of the ratio of inclusive jet cross sections using the anti-kt algorithm with radius parameters R = 0.5 and 0.7 in pp collisions at sqrt(s) = 7 TeV. Physical Review D, 2014, 90, pp.072006. ⟨10.1103/PhysRevD.90.072006⟩. ⟨in2p3-00998919⟩
  • V. Khachatryan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for excited quarks in the photon+jet final state in proton-proton collisions at sqrt(s) = 8 TeV. Physics Letters B, 2014, 738, pp.274-293. ⟨10.1016/j.physletb.2014.09.048⟩. ⟨in2p3-01010551⟩
  • V.M. Abazov, G. Bernardi, D. Brown, Y. Enari, S. Greder, et al.. Measurement of the forward-backward asymmetry in the distribution of leptons in t\bar{t} events in the lepton+jets channel. Physical Review D, 2014, 90, pp.072001. ⟨10.1103/PhysRevD.90.072001⟩. ⟨in2p3-00956640⟩

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