Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for dark matter particles produced in association with a Higgs boson in proton-proton collisions at \sqrt{\mathrm{s}} = 13 TeV. JHEP, 2020, 03, pp.025. ⟨10.1007/JHEP03(2020)025⟩. ⟨hal-02290762⟩
    • A. Arbey, J. Auffinger, K.P. Hickerson, E.S. Jenssen. AlterBBN v2: A public code for calculating Big-Bang nucleosynthesis constraints in alternative cosmologies. Computer Physics Communications, 2020, 248, pp.106982. ⟨10.1016/j.cpc.2019.106982⟩. ⟨hal-01839701⟩
    • Diogo Buarque Franzosi, Giacomo Cacciapaglia, Aldo Deandrea. Sigma-assisted low scale composite Goldstone–Higgs. European Physical Journal C: Particles and Fields, 2020, 80 (1), pp.28. ⟨10.1140/epjc/s10052-019-7572-z⟩. ⟨hal-01897260⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Longitudinal and azimuthal evolution of two-particle transverse momentum correlations in Pb-Pb collisions at \sqrt{s_{\rm{NN}}} = 2.76 TeV. Phys.Lett.B, 2020, 804, pp.135375. ⟨10.1016/j.physletb.2020.135375⟩. ⟨hal-02382012⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Evidence of rescattering effect in Pb-Pb collisions at the LHC through production of \rm{K}^{*}(892)^{0} and \phi(1020) mesons. Phys.Lett.B, 2020, 802, pp.135225. ⟨10.1016/j.physletb.2020.135225⟩. ⟨hal-02382010⟩
    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Measurement of the (anti-)3He elliptic flow in Pb–Pb collisions at sNN=5.02TeV. Phys.Lett.B, 2020, 805, pp.135414. ⟨10.1016/j.physletb.2020.135414⟩. ⟨hal-02383328⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Centrality and transverse momentum dependence of inclusive J/ψ production at midrapidity in Pb–Pb collisions at sNN=5.02 TeV. Phys.Lett.B, 2020, 805, pp.135434. ⟨10.1016/j.physletb.2020.135434⟩. ⟨hal-02383422⟩
    • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Non-linear flow modes of identified particles in Pb-Pb collisions at \sqrt{s_{\mathrm{NN}}} = 5.02 TeV. Journal of High Energy Physics, 2020, 06, pp.147. ⟨10.1007/JHEP06(2020)147⟩. ⟨hal-02416905⟩
    • Alexandre Arbey, Jérémy Auffinger, Joseph Silk. Evolution of primordial black hole spin due to Hawking radiation. Monthly Notices of the Royal Astronomical Society, 2020, 494 (1), pp.1257-1262. ⟨10.1093/mnras/staa765⟩. ⟨hal-02165581⟩
    • C. Amsler, M. Antonello, A. Belov, G. Bonomi, R.S. Brusa, et al.. A cryogenic tracking detector for antihydrogen detection in the AEgIS experiment. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2020, 960, pp.163637. ⟨10.1016/j.nima.2020.163637⟩. ⟨hal-02507897⟩

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