Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Production of charged pions, kaons, and (anti-)protons in Pb-Pb and inelastic pp collisions at \sqrt {s_{NN}} = 5.02 TeV. Physical Review C, 2020, 101 (4), pp.044907. ⟨10.1103/PhysRevC.101.044907⟩. ⟨hal-02382025⟩
  • B. Cederwall, X. Liu, Ö. Aktas, A. Ertoprak, W. Zhang, et al.. Isospin Properties of Nuclear Pair Correlations From the Level Structure of the Self-Conjugate Nucleus ^{88}Ru. Physical Review Letters, 2020, 124 (6), pp.062501. ⟨10.1103/PhysRevLett.124.062501⟩. ⟨hal-02491326⟩
  • M. Ciemala, S. Ziliani, F.C.L. Crespi, S. Leoni, B. Fornal, et al.. Testing ab initio nuclear structure in neutron-rich nuclei: lifetime measurements of second 2^+ states in ^{16}C and ^{20}O. Physical Review C, 2020, 101 (2), pp.021303. ⟨10.1103/PhysRevC.101.021303⟩. ⟨hal-02483950⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Extraction and validation of a new set of CMS PYTHIA8 tunes from underlying-event measurements. European Physical Journal C: Particles and Fields, 2020, 80 (1), pp.4. ⟨10.1140/epjc/s10052-019-7499-4⟩. ⟨hal-02101686⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. A deep neural network to search for new long-lived particles decaying to jets. Mach.Learn.Sci.Tech., 2020, 1, pp.035012. ⟨10.1088/2632-2153/ab9023⟩. ⟨hal-02447856⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Determination of the strong coupling constant \alpha_{S}(m_\mathrm{Z}) from measurements of inclusive W^\pm and Z boson production cross sections in proton-proton collisions at \sqrt{\mathrm{s}} = 7 and 8 TeV. Journal of High Energy Physics, 2020, 06, pp.018. ⟨10.1007/JHEP06(2020)018⟩. ⟨hal-02431448⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurements of the W boson rapidity, helicity, double-differential cross sections, and charge asymmetry in pp collisions at \sqrt {s} = 13 TeV. Physical Review D, 2020, 102 (9), pp.092012. ⟨10.1103/PhysRevD.102.092012⟩. ⟨hal-02933975⟩
  • R. Avigo, O. Wieland, A. Bracco, F. Camera, F. Ameil, et al.. Low-lying electric dipole γ-continuum for the unstable ^{62,64}Fe nuclei: Strength evolution with neutron number. Physics Letters B, 2020, 811, pp.135951. ⟨10.1016/j.physletb.2020.135951⟩. ⟨hal-03047536⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for Supersymmetry with a Compressed Mass Spectrum in Events with a Soft \tau Lepton, a Highly Energetic Jet, and Large Missing Transverse Momentum in Proton-Proton Collisions at \sqrt{s}= TeV. Phys.Rev.Lett., 2020, 124 (4), pp.041803. ⟨10.1103/PhysRevLett.124.041803⟩. ⟨hal-02327739⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of top quark pair production in association with a Z boson in proton-proton collisions at \sqrt{s}= 13 TeV. JHEP, 2020, 03, pp.056. ⟨10.1007/JHEP03(2020)056⟩. ⟨hal-02528314⟩

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