Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • B. Kubik, R. Barbier, A. Castera, E. Chabanat, S. Ferriol, et al.. Predictive model of the temporal noise correlations in HgCdTe array. 7th International Conference on New Developments in Photodetection - NDIP14, Jun 2014, Tours, France. pp.315-318, ⟨10.1016/j.nima.2015.01.011⟩. ⟨in2p3-01160146⟩
  • T. Cajgfinger, A. Dominjon, R. Barbier. Single photon detection and localization accuracy with an ebCMOS camera. 7th International Conference on New Developments in Photodetection - NDIP14, Jun 2014, Tours, France. pp.176-181, ⟨10.1016/j.nima.2014.11.090⟩. ⟨in2p3-01160134⟩
  • T. Brugière, F. Mayer, P. Fereyre, C. GuĂ©rin, A. Dominjon, et al.. First measurement of the in-pixel electron multiplying with a standard imaging CMOS technology: Study of the EMCMOS concept. 7th International Conference on New Developments in Photodetection - NDIP14, Jun 2014, Tours, France. pp.336-339, ⟨10.1016/j.nima.2015.01.065⟩. ⟨in2p3-01160144⟩
  • SĂ©bastien Brochet. Recherche de physique au-delĂ  du Modèle Standard dans le secteur du quark top et calibration de l’échelle en Ă©nergie des jets avec l’expĂ©rience CMS du LHC. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2014. Français. ⟨NNT : 2014LYO10108⟩. ⟨tel-01089260v2⟩
  • Sacha Davidson. Axions Bose and Classical Fields. 10th PATRAS Workshop on Axions, WIMPs and WISPs, Jun 2014, Genève, Switzerland. ⟨in2p3-00976010⟩
  • L. Sarrasin, C. Gaillard, N. BĂ©rerd, Maria Yu Boltoeva, S. Georg, et al.. Use of ionic liquids for uranium recovery: are they stable to irradiation?. 2nd international conference on Ionic Liquids in SEparation and Purification Technology (ILSEPT), Jun 2014, Toronto, Canada. ⟨in2p3-02094054⟩
  • Sacha Davidson. The Pressure of Misalignment Axions: a Difference from WIMPs in Galaxy Formation?. 10th Patras Workshop on Axions, WIMPs and WISPs, Jun 2014, Genève, Switzerland. ⟨in2p3-01077213⟩
  • Maria Yu Boltoeva, A. Aoudi, S. Georg, V. Mazan, A. Turanov, et al.. Solvent extraction of actinides, lanthanides and transition metals in the presence of ionic liquids. 2nd international conference on Ionic Liquids in SEparation and Purification Technology (ILSEPT), Jun 2014, Toronto, Canada. ⟨in2p3-02093824⟩
  • M. Beuve. The track-structure :incidence on biologic effect. ITN SPRITE Training Event #5 Basics of Particle-Matter Interaction and Damage Processes and Radiation Protection Issues, Jun 2014, Caen, France. ⟨hal-01118694⟩
  • Bogna Kubik, Remi Barbier, Alain Castera, Eric Chabanat, Sylvain Ferriol, et al.. Impact of noise covariance and nonlinearities in NIR H2RG detectors. SPIE Astronomical Telescopes + Instrumentation 2014, Jun 2014, Montreal, Canada. pp.91541Q, ⟨10.1117/12.2055318⟩. ⟨hal-02097425⟩

Powered by HAL logo