Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Gascon. Direct dark matter searches review. 3rd International Conference on New Frontiers in Physics, Jul 2014, Kolymbari, Crete, Greece. pp.02004, ⟨10.1051/epjconf/20159502004⟩. ⟨in2p3-01170648⟩
  • Denis Dauvergne, E. Testa. Prompt gamma imaging for proton and carbon therapy. Joint ESTRO-AAPM symposium 56th Annual Meeting AAPM, Jul 2014, Austin, United States. ⟨hal-01115917⟩
  • J. Gascon. Review of Dark Matter Direct Searches. 14th annual international symposium “Frontiers of Fundamental Physics” (FFP14), Jul 2014, Marseille, France. pp.052. ⟨in2p3-01234008⟩
  • Sacha Davidson. Leptogenesis. Strong and Electroweak Matter (SEWM14), Jul 2014, Lausanne, Switzerland. ⟨in2p3-00976003⟩
  • F. Aymard, F. Gulminelli, J. Margueron. Sub-saturation matter in compact stars: Nuclear modelling in the framework of the extended Thomas-Fermi theory. Carpathian Summer School of Physics 2014, Jul 2014, Sinaia, Romania. pp.291-295, ⟨10.1063/1.4909588⟩. ⟨in2p3-01023922⟩
  • Louis Sgandurra. Calibration du calorimètre Ă©lectromagnĂ©tique Ă  l’aide des Ă©vĂ©nements Z -> µµγ et recherches de bosons de Higgs additionnels dans le canal H -> γγ dans l’expĂ©rience CMS au LHC. Physique Atomique [physics.atom-ph]. UniversitĂ© Claude Bernard - Lyon I, 2014. Français. ⟨NNT : 2014LYO10135⟩. ⟨tel-01138712v2⟩
  • D. V. Poda, E. Armengaud, Q. Arnaud, C. Augier, A. BenoĂ®t, et al.. Scintillating bolometers based on ZnMoO_4 and Zn^{100}MoO_4 crystals to search for 0\nu2\beta decay of ^{100}Mo (LUMINEU project): first tests at the Modane Underground Laboratory. 37th International Conference on High Energy Physics (ICHEP 2014), Jul 2014, Valencia, Spain. ⟨in2p3-01128035⟩
  • V. Galymov. The LAGUNA-LBNO neutrino observatory in Europe. 37th International Conference on High Energy Physics (ICHEP 2014), Jul 2014, Valencia, Spain. pp.1854-1860, ⟨10.1016/j.nuclphysbps.2015.09.299⟩. ⟨in2p3-01331160⟩
  • M. Calviani, S. Di Luise, V. Galymov, P. Velten. Optimization of neutrino fluxes for future long baseline neutrino oscillation experiments. 37th International Conference on High Energy Physics, Jul 2014, Valencia, Spain. pp.2681-2683, ⟨10.1016/j.nuclphysbps.2015.10.029⟩. ⟨hal-01554964⟩
  • J. Krimmer, J.-L. Ley, C. Abellan, J.-P. Cachemiche, L. Caponetto, et al.. Development of a Compton Camera for medical applications based on SSD and scintillation detectors. NDIP'2014, 7th International Conference on New Developments in Photodetection, Jun 2014, Tours, France. ⟨in2p3-01071940⟩

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