Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • N. Chamel, J.M. Pearson, A.F. Fantina, C. Ducoin, S. Goriely, et al.. Brussels–Montreal Nuclear Energy Density Functionals, from Atomic Masses to Neutron Stars. Zakopane Conference on Nuclear Physics Extremes of the Nuclear Landscape, Aug 2014, Zakopane, Poland. pp.349-358, ⟨10.5506/APhysPolB.46.349⟩. ⟨in2p3-01152712⟩
  • D. Autiero. LBNO-DEMO at CERN and beyond. OPEN LAGUNA 2014 Event, Aug 2014, Helsinki, Finland. ⟨in2p3-02108188⟩
  • Katrin Tanzer, Linda Feketeova, Benjamin Puschnigg, Paul Scheier, E. Illenberger, et al.. Low energy electron attachment to nitroimidazole. 27th Summer School and International Symposium on the Physics of Ionized Gases (SPIG 2014), Aug 2014, Belgrade, Serbia. ⟨in2p3-02081046⟩
  • N. Lalović, R. M. Perez-Vidal, C. Louchart, C. Michelagnoli, D. Ralet, et al.. Analysis of the Response of AGATA Detectors at GSI. Fifteenth International Symposium on Capture Gamma-Ray Spectroscopy and Related Topics (CGS15), Aug 2014, Dresden, Germany. pp.07007, ⟨10.1051/epjconf/20159307007⟩. ⟨in2p3-01161752⟩
  • P. Jardin, C. Barué, C. Canet, P. Delahaye, M. Dubois, et al.. Status on current and future ECRISs developments at GANIL. 21st International Workshop on ECR Ion Sources (ECRIS 2014), Aug 2014, Nizhny Novgorod, Russia. ⟨in2p3-01057668⟩
  • J.-M. Régis, J. Jolie, H. Mach, G.S. Simpson, A. Blazhev, et al.. The Generalized Centroid Difference method for lifetime mesaurements via \gamma-\gamma coincidences using large fast-timing arrays. Fifteenth International Symposium on Capture Gamma-Ray Spectroscopy and Related Topics (CGS15), Aug 2014, Dresden, Germany. pp.01013, ⟨10.1051/epjconf/20159301013⟩. ⟨in2p3-01077155⟩
  • Viola Sordini. Pileup mitigation techniques in jets at CMS. Getting ready for 13TeV : Vienna workshop on jets and missing energy, Aug 2014, Vienne, Austria. ⟨hal-02018877⟩
  • P. Costa, M. Ferreira, C. Providência, H. Hansen, D.P. Menezes. The QCD critical end point driven by an external magnetic field in asymmetric quark matter. 20th International Conference on Particles and Nuclei (PANIC 14), Aug 2014, Hambourg, Germany. ⟨10.3204/DESY-PROC-2014-04/75⟩. ⟨in2p3-01247446⟩
  • F. Lemagnen, C. Barué, C. Canet, M. Dupuis, J.L. Flambard, et al.. Production of metallic stable ion beams for GANIL and SPIRAL2. 21st International Workshop on ECR Ion Sources (ECRIS 2014), Aug 2014, Nizhny Novgorod, Russia. pp.45-48. ⟨in2p3-01057669⟩
  • V. Sordini. CMS Pileup mitigations developments for Run2. 6th International Conference on Boosted Objects Phenomenology, Reconstruction and Searches in HEP, Aug 2014, Londres, United Kingdom. ⟨hal-02018847⟩

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