Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D. Tsimpis. G-structures and generalized geometry. Workshop on quantum fields and strings 2014, Sep 2014, Corfou, Greece. ⟨in2p3-01107231⟩
  • C. Kéfélian. Status of the EDELWEISS-III Dark Matter search. 2nd Workshop on Germanium Detectors and Technologies, Sep 2014, South Dakota, United States. pp.012002, ⟨10.1088/1742-6596/606/1/012002⟩. ⟨in2p3-01170828⟩
  • I. Jozwik, J. Jagielski, G. Gawlik, Gérard Panczer, N. Moncoffre, et al.. Ion beam-induced luminescence as method of characterization of radiation damage in polycrystalline materials. 19th International Conference on Ion Beam Modification of Materials (IBMM 2014), Sep 2014, Leuven, Belgium. pp.273-277, ⟨10.1016/j.nimb.2015.07.056⟩. ⟨in2p3-01251362⟩
  • G. Cacciapaglia. Fundamental composite Higgs dynamics. 11th Conference on Quark Confinement and the Hadron Spectrum (Confinement XI), Sep 2014, Saint Petersburg, Russia. pp.090002, ⟨10.1063/1.4938704⟩. ⟨in2p3-01279404⟩
  • J. Storey, P. Nedelec. Particle tracking at cryogenic temperatures: the Fast Annihilation Cryogenic Tracking (FACT) detector for the AEgIS antimatter gravity experiment. PSD10:10th International Conference on Position Sensitive Detectors (PSD10), Sep 2014, Surrey, United Kingdom. pp.C02023, ⟨10.1088/1748-0221/10/02/C02023⟩. ⟨in2p3-01141880⟩
  • Benoît Marchand, N. Moncoffre, Y. Pipon, N. Bérerd, Louis Raimbault, et al.. New data processing for SIMS. SIMS Europe, Sep 2014, Münster, Germany. ⟨in2p3-02096004⟩
  • Pierrick Guiral, Julien Ribouton, Patrice Jalade, Patrick Pittet, Ruoxi Wang, et al.. Characterization of Gallium Nitride radioluminescent transducers for Dosimetry and Quality Assurance in HDR Brachytherapy. 8th European Conference on Medical Physics (ECMP 2014), Sep 2014, Athens, Greece. ⟨hal-02021164⟩
  • J. Constanzo, M. Fallavier, G. Alphonse, C. Bernard, P. Battiston-Montagne, et al.. Radiograaff, a proton irradiation facility for radiobiological studies at a 4MV Van de Graaff accelerator. Nuclear Instruments and Methods in Physics Research, 2014, 334, pp.52-58. ⟨10.1016/j.nimb.2014.05.005⟩. ⟨hal-01115753⟩
  • Iwona Jozwik, Jacek Jagielski, Grzegorz Gawlik, Przemyslaw Jozwik, Renata Ratajczak, et al.. Analysis of Radiation Damage in Magnesium Aluminate Spinel by Means of Cathodoluminescence. 9th International Conference on Charged Particle Optics (CPO-9), Aug 2014, Brno, Czech Republic. pp.1005-1006, ⟨10.1017/S1431927615005826⟩. ⟨hal-03323251⟩
  • T. Alexander, Z. Podolyák, M.L. Cortes, J. Gerl, D. Rudolph, et al.. Isomeric Ratios in 206Hg. The Zakopane Conference on Nuclear Physics “Extremes of the Nuclear Landscape”,, Aug 2014, Zakopane, Poland. pp.601-605, ⟨10.5506/APhysPolB.46.601⟩. ⟨in2p3-01150949⟩

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