Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- X. Artru. Classical and quantum phenomenology in radiation by relativistic electrons in matter or in external fields. 6th International Conference - Channeling 2014 Charged & Neutral Particles Channeling Phenomena, Oct 2014, Capri, Italy. pp.11-16, ⟨10.1016/j.nimb.2015.03.082⟩. ⟨in2p3-01092699⟩
- J. Remillieux, X. Artru, M. Bajard, R. Chehab, M. Chevallier, et al.. High energy channelling and the experimental search for the internal clock predicted by Louis de Broglie. 6th International Conference “Channeling 2014: Charged & Neutral Particles Channeling Phenomena”, Oct 2014, Capri, Italy. pp.193-197, ⟨10.1016/j.nimb.2015.02.005⟩. ⟨in2p3-01183086⟩
- Catherine Matias, Katrin Tanzer, Linda Feketeová, Paul Scheier, Eugen Illenberger, et al.. Inelastic electron interaction (ionization/attachment) with nitroimidazole. Workshop on Translational Research Ion Beam Cancer Therapy (TRIBCT 2014), Sep 2014, Skejby, Denmark. ⟨in2p3-02082714⟩
- C. Aufranc. Base de donnĂ©es de construction d'AGATA. Rencontre AGATA France, Sep 2014, Orsay, France. ⟨in2p3-02101699⟩
- D. Dauvergne. Ion-range measurements using Time-of-Flight prompt gamma measurements. Workshop on Range Assessment and Dose Verification in Particle Therapy Dresden 2014, Sep 2014, Dresden, Germany. ⟨hal-01118648⟩
- A. L. Pequegnot. Search for ttbar resonances in the semileptonic final state using pp collisions data recorded with the CMS detector. 7th International Workshop on Top Quark Physics (TOP2014), Sep 2014, Cannes, France. ⟨in2p3-02014499⟩
- E. Testa, D. Dauvergne. Interaction vertex imaging for carbon ion therapy monitoring : measured and simulated vertex. Workshop on Range Assessment and Dose Verification in Particle Therapy Dresden 2014, Sep 2014, Dresden, Germany. ⟨hal-01118651⟩
- Robin Jodon. Ajustements de fonctionnelles de Skyrme gĂ©nĂ©ralisĂ©es. Physique NuclĂ©aire ExpĂ©rimentale [nucl-ex]. UniversitĂ© Claude Bernard - Lyon I, 2014. Français. ⟨NNT : 2014LYO10170⟩. ⟨tel-01158085v2⟩
- G. Consolati, P. NĂ©dĂ©lec. Experiments with low-energy antimatter. Dark Matter, Hadron Physics and Fusion Physics, Sep 2014, Messina, Italy. pp.01007, ⟨10.1051/epjconf/20159601007⟩. ⟨in2p3-01170650⟩
- D. Davesne, J. Meyer, A. Pastore, J. Navarro. Partial wave decomposition of the N3LO equation of state. XXI Nuclear Physics Workshop 'Marie & Pierre Curie' on Essential Problems in Nuclear Physics, Sep 2014, Kazimierz Dolny, Poland. pp.114002 ⟨10.1088/0031-8949/90/11/114002⟩. ⟨in2p3-01084757⟩
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