Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
546 documents

  • Ilaria Rinaldi, Ludovic de Marzi, Annalisa Patriarca, Giuseppe Pitta, Nils Krah. High WET resolution proton radiography using dedicated image processing methods and a commercial plug'n'play detector. Proton Imaging Workshop Lyon 2018, Jun 2018, Lyon, France. ⟨hal-02048584⟩
  • Nils Krah. A comprehensive theoretical comparison of proton imaging set-ups in terms of spatial resolution. Proton Imaging Workshop Lyon 2018, Jun 2018, Lyon, France. ⟨hal-02048546⟩
  • Yasmine Ali, Michael Beuve, A. Carnicer, E. Debiton, F. Degoul, et al.. Simulation de la dose biologique produite par des protons de 65 MeV (faisceau clinique) et des ions carbone. congrès de la SociĂ©tĂ© Française de Physique MĂ©dicale, Jun 2018, Toulouse, France. ⟨hal-02083082⟩
  • Nils Krah, Feriel Khellaf, Jean Michel LĂ©tang, Simon Rit, Ilaria Rinaldi. Which proton imaging set-up should we use in a proton therapy facility?. 57th Annual Meeting of the Particle Therapy Cooperative Group (PTCOG), May 2018, Cincinnati, United States. ⟨hal-02050814⟩
  • Anne-Sophie Wozny, Guillaume Vares, Tetsuo Nakajima, Akira Fujimori, Michael Beuve, et al.. Role of HIF-1α in the migration/invasion processes in response to photon and C-ion irradiations. ESTRO 37 - Innovation for Value and Access, Apr 2018, Barcelona, Spain. ⟨hal-02064756⟩
  • Giovanna Muggiolu, Sarah Libert, Alexandra Lauret, Philippe CĂ©ruse, Christian Adrien Righini, et al.. Stratification of Head and Neck Cancers: DNA Repair Enzyme Signature to Identify Resistance and Toxicity Biomarkers. Forum de la recherche en CancĂ©rologie 2018, Apr 2018, Villeurbanne, France. ⟨hal-01990547⟩
  • Alexandra Lauret, Pierre Philouze, CĂ©line MalĂ©sys, Philippe CĂ©ruse, Jonathan Lopez, et al.. Comparaison du profil d’expression gĂ©nique de biopsies et de cellules tumorales circulantes dans le suivi thĂ©rapeutique des cancers des VADS. Forum de la recherche en CancĂ©rologie 2018, Apr 2018, Villeurbanne, France. ⟨hal-01990828⟩
  • Anne-Sophie Wozny, Gersende Alphonse, Guillaume Vares, Caterina Monini, Jean-Baptiste Guy, et al.. La distribution spatiale des radicaux libres oxygĂ©nĂ©s permet d’expliquer la diffĂ©rence d’activation des processus d’invasion/migration des cellules souches cancĂ©reuses en rĂ©ponse aux photons et aux ions carbone. Forum de la recherche en CancĂ©rologie 2018, Apr 2018, Villeurbanne, France. ⟨hal-01990890⟩
  • Floriane Poignant, BenoĂ®t Gervais, Andrei Ipatov, Hela Charfi, Etienne Testa, et al.. ModĂ©lisation physique, chimique et biologique pour la radiothĂ©rapie amĂ©liorĂ©e par les nanoparticules Ă  fort-Z : vers une meilleure comprĂ©hension de l’effet radiosensibilisant. Forum de la recherche en CancĂ©rologie 2018, Apr 2018, Villeurbanne, France. ⟨hal-01989615⟩
  • Caterina Monini, Etienne Testa, Michael Beuve. NanOx, a New Multiscale Model to Predict Ion RBE in Hadrontherapy. Forum de la recherche en CancĂ©rologie 2018, Apr 2018, Villeurbanne, France. ⟨hal-01989470⟩

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