Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • Katrin Tanzer, Linda Feketeová, Paul Scheier, Eugen Illenberger, S. Denifl, et al.. Inelastic electron interaction (ionization/attachment) with nitroimidazole. 3rd Nano-IBCT Conference 2014, Radiation damage of biomolecular systems: Nano-scale insights into Ion Beam Cancer Therapy (Nano-IBCT 2014), Oct 2014, Boppard, Germany. ⟨in2p3-02082724⟩
    • N. Moncoffre, N. Toulhoat, N. Bérerd, Y. Pipon, G. Silbermann, et al.. Impact of radiolysis and radiolytic corrosion on the release of ^{13}C and ^{37}Cl implanted into nuclear graphite: Consequences for the behaviour of ^{14}C and ^{36}Cl in gas cooled graphite moderated reactors. Nuclear Material conference (NuMat), Oct 2014, Clearwater Beach, United States. ⟨in2p3-02096474⟩
    • N Toulhoat, N Moncoffre, N. Bererd, Y Pipon, Antoine Blondel, et al.. Ion irradiation of ^{37}Cl implanted nuclear graphite: Effect of the energy deposit on the chlorine behavior and consequences for the mobility of ^{36}Cl in irradiated graphite. Nuclear Material conference (NuMat), Oct 2014, Clearwater Beach, United States. ⟨in2p3-02093840⟩
    • M. Le Guillou, Y Pipon, N Moncoffre, N Toulhoat, N. Bérerd, et al.. Deuterium migration in nuclear graphite : consequences for the behavior of tritium in CO2 cooled reactors and for purification of irradiated graphite. Nuclear Material conference (NuMat), Oct 2014, Clearwater Beach, United States. ⟨in2p3-02093973⟩
    • Dominique Gibert, Jacques Marteau, Jean de Bremond d'Ars, Kevin Jourde, Serge Gardien, et al.. Radiographier les volcans avec des rayons cosmiques : instrumentation et applications. 24 ème Réunion des sciences de la Terre 2014, Oct 2014, Pau, France. pp.486. ⟨insu-01080883⟩
    • Nicolas Galy, N Moncoffre, N Toulhoat, N. Bérerd, Y Pipon, et al.. In situ Raman spectroscopy for characterization of irradiation induced defects in graphite. Nuclear Material conference (NuMat), Oct 2014, Clearwater Beach, United States. ⟨in2p3-02093969⟩
    • J. Krimmer. Detection of Prompt Secondary Radiation for Ion Range Monitoring. Precision, Speed and Flexibility: New radiation detection methods for ion beam radiotherapy, DKFZ Heidelberg 2014, Oct 2014, Heidelberg, Germany. ⟨hal-01118834⟩
    • M. Gouzevitch. Boosted Higgs as key to searches for new physics. Hamburg workshop on Higgs physics, Oct 2014, Hambourg, Germany. ⟨hal-02075678⟩
    • Maël Le Guillou. Migration du deutérium dans le graphite nucléaire : conséquences sur le comportement du tritium en réacteur UNGG et sur la décontamination des graphites irradiés. Physique Nucléaire Expérimentale [nucl-ex]. Université Claude Bernard - Lyon I, 2014. Français. ⟨NNT : 2014LYO10227⟩. ⟨tel-01128210⟩
    • D. Gorse-Pomonti, N. Dragoe, M-G Barthes-Labrousse, E Garcia-Caurel, N. Bérerd. Corrosion of titanium and zirconium under Ar irradiation in the low MeV range: an XPS and SE study. International Conference on Thin Film (ICTF16), Oct 2014, Dubrovnik, Croatia. ⟨in2p3-02094812⟩

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