Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Dominique Gibert, Jacques Marteau, Jean de Bremond d'Ars, Kevin Jourde, Serge Gardien, et al.. Radiographier les volcans avec des rayons cosmiques : instrumentation et applications. 24 ème RĂ©union des sciences de la Terre 2014, Oct 2014, Pau, France. pp.486. ⟨insu-01080883⟩
  • Nicolas Galy, N Moncoffre, N Toulhoat, N. BĂ©rerd, Y Pipon, et al.. In situ Raman spectroscopy for characterization of irradiation induced defects in graphite. Nuclear Material conference (NuMat), Oct 2014, Clearwater Beach, United States. ⟨in2p3-02093969⟩
  • J. Krimmer. Detection of Prompt Secondary Radiation for Ion Range Monitoring. Precision, Speed and Flexibility: New radiation detection methods for ion beam radiotherapy, DKFZ Heidelberg 2014, Oct 2014, Heidelberg, Germany. ⟨hal-01118834⟩
  • M. Gouzevitch. Boosted Higgs as key to searches for new physics. Hamburg workshop on Higgs physics, Oct 2014, Hambourg, Germany. ⟨hal-02075678⟩
  • MaĂ«l Le Guillou. Migration du deutĂ©rium dans le graphite nuclĂ©aire : consĂ©quences sur le comportement du tritium en rĂ©acteur UNGG et sur la dĂ©contamination des graphites irradiĂ©s. Physique NuclĂ©aire ExpĂ©rimentale [nucl-ex]. UniversitĂ© Claude Bernard - Lyon I, 2014. Français. ⟨NNT : 2014LYO10227⟩. ⟨tel-01128210⟩
  • D. Gorse-Pomonti, N. Dragoe, M-G Barthes-Labrousse, E Garcia-Caurel, N. BĂ©rerd. Corrosion of titanium and zirconium under Ar irradiation in the low MeV range: an XPS and SE study. International Conference on Thin Film (ICTF16), Oct 2014, Dubrovnik, Croatia. ⟨in2p3-02094812⟩
  • N. Galy, N Toulhoat, N Moncoffre, N. BĂ©rerd, Y Pipon, et al.. Effets de l’irradiation sur le comportement du ^{13}C et du ^{37}Cl implantĂ©s dans le graphite. BAF 2014 - Ion Beam Analysis Francophone - 5e Rencontre "analyse par faisceaux d'ions rapides", Oct 2014, Obernai, France. ⟨in2p3-02094816⟩
  • G. Victor, Y. Pipon, N. BĂ©rerd, N. Toulhoat, N. Moncoffre, et al.. Etude des Ă©volutions Ă©lĂ©mentaires et structurales induites par l’irradiation et la tempĂ©rature dans le carbure de Bore B_4C. IBAF 2014 - Ion Beam Analysis Francophone - 5e Rencontre "analyse par faisceaux d'ions rapides", SociĂ©tĂ© Française du Vide, Oct 2014, Obernai, France. ⟨hal-01104508⟩
  • M. Le Guillou, N Moncoffre, N Toulhoat, Y Pipon, N. BĂ©rerd, et al.. Migration du Deuterium dans le graphite nucleaire : consĂ©quences sur le comportement du Tritium dans des rĂ©acteurs de type UNGG et sur la dĂ©contamination des graphites irradiĂ©s. BAF 2014 - Ion Beam Analysis Francophone - 5e Rencontre "analyse par faisceaux d'ions rapides", Oct 2014, Obernai, France. ⟨in2p3-02094814⟩
  • Dominique Gosset, Vianney Motte, Suzy SurblĂ©, Nathalie Moncoffre. Analyse par NRA de la diffusion de l’helium dans le carbure de Bore B4C. Ion Beam Analysis Francophone (IBAF 2014), Oct 2014, Obernai, France. ⟨cea-02362658⟩

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