Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • N. Arbor, Jean Michel LĂ©tang, D. Dauvergne, E. Testa, G. Dedes, et al.. In-silico comparison of X-ray and proton computed tomography for proton therapy dose simulation with a full Monte Carlo treatment planning. IEEE Nuclear Science Symposium & Medical Imaging Conference, Nov 2014, Seattle, United States. ⟨hal-01054233⟩
  • M. Dahoumane, D. Dauvergne, J. Krimmer, J.-L. Ley, E. Testa, et al.. A Low Noise and High Dynamic Range CMOS Integrated Electronics associated with Double Sided Silicon Strip Detectors for a Compton Camera gamma-ray Detecting System. NSS-MIC, Nov 2014, Seattle, United States. ⟨hal-01131450⟩
  • D. Contardo. The Experimental Challenges of the High Luminosity LHC. Heraeus-seminar - Physics Landscape after the Higgs Discovery at the LHC, Nov 2014, Bad Honef, Germany. ⟨hal-02064031⟩
  • Katrin Tanzer, Linda Feketeová, Benjamin Puschnigg, Paul Scheier, Eugen Illenberger, et al.. Reaktionen in Nitroimidazol, ausgelöst durch niederenergetische (0 - 2 eV) Elektronen: Methylierung an N1-H blockiert die Reaktivität. Angewandte Chemie, 2014, 126 (45), pp.12437-12440. ⟨10.1002/ange.201407452⟩. ⟨in2p3-02087331⟩
  • Katrin Tanzer, Linda Feketeová, Benjamin Puschnigg, Paul Scheier, Eugen Illenberger, et al.. Reactions in Nitroimidazole Triggered by Low-Energy (0 - 2 eV) Electrons: Methylation at N1-H Completely Blocks Reactivity. Angewandte Chemie International Edition, 2014, 53 (45), pp.12240-12243. ⟨10.1002/anie.201407452⟩. ⟨in2p3-02087330⟩
  • N. Moncoffre, N. Toulhoat, N. BĂ©rerd, Y. Pipon, G. Silbermann, et al.. Impact of radiolysis and radiolytic corrosion on the release of ^{13}C and ^{37}Cl implanted into nuclear graphite: Consequences for the behaviour of ^{14}C and ^{36}Cl in gas cooled graphite moderated reactors. Nuclear Material conference (NuMat), Oct 2014, Clearwater Beach, United States. ⟨in2p3-02096474⟩
  • Katrin Tanzer, Linda Feketeová, Paul Scheier, Eugen Illenberger, S. Denifl, et al.. Inelastic electron interaction (ionization/attachment) with nitroimidazole. 3rd Nano-IBCT Conference 2014, Radiation damage of biomolecular systems: Nano-scale insights into Ion Beam Cancer Therapy (Nano-IBCT 2014), Oct 2014, Boppard, Germany. ⟨in2p3-02082724⟩
  • N Toulhoat, N Moncoffre, N. Bererd, Y Pipon, Antoine Blondel, et al.. Ion irradiation of ^{37}Cl implanted nuclear graphite: Effect of the energy deposit on the chlorine behavior and consequences for the mobility of ^{36}Cl in irradiated graphite. Nuclear Material conference (NuMat), Oct 2014, Clearwater Beach, United States. ⟨in2p3-02093840⟩
  • M. Le Guillou, Y Pipon, N Moncoffre, N Toulhoat, N. BĂ©rerd, et al.. Deuterium migration in nuclear graphite : consequences for the behavior of tritium in CO2 cooled reactors and for purification of irradiated graphite. Nuclear Material conference (NuMat), Oct 2014, Clearwater Beach, United States. ⟨in2p3-02093973⟩
  • Dominique Gibert, Jacques Marteau, Jean de Bremond d'Ars, Kevin Jourde, Serge Gardien, et al.. Radiographier les volcans avec des rayons cosmiques : instrumentation et applications. 24 ème RĂ©union des sciences de la Terre 2014, Oct 2014, Pau, France. pp.486. ⟨insu-01080883⟩

Powered by HAL logo