Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Measurement of the W+b-jet and W+c-jet differential production cross sections in p\bar{p} collisions at \sqrt{s}=1.96 TeV. Physics Letters B, 2015, 743, pp.6-14. ⟨10.1016/j.physletb.2015.02.012⟩. ⟨in2p3-01096711⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for heavy Majorana neutrinos in mu+/- mu+/- + jets events in proton-proton collisions at sqrt(s) = 8 TeV. Physics Letters B, 2015, 748, pp.144-166. ⟨10.1016/j.physletb.2015.06.070⟩. ⟨in2p3-01128340⟩
  • V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Measurement of the forward-backward asymmetry in the production of B^{\pm} mesons in p\bar{p} collisions at \sqrt{s} = 1.96 TeV. Physical Review Letters, 2015, 114 (5), pp.051803. ⟨10.1103/PhysRevLett.114.051803⟩. ⟨in2p3-01082229⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for a charged Higgs boson in pp collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2015, 2015(11), pp.18. ⟨10.1007/JHEP11(2015)018⟩. ⟨in2p3-01188996⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Searches for third generation squark production in fully hadronic final states in proton-proton collisions at sqrt(s)=8 TeV. Journal of High Energy Physics, 2015, 1506, pp.116. ⟨10.1007/JHEP06(2015)116⟩. ⟨in2p3-01139106⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Precise determination of the mass of the Higgs boson and tests of compatibility of its couplings with the standard model predictions using proton collisions at 7 and 8 TeV. European Physical Journal C: Particles and Fields, 2015, 75, pp.212. ⟨10.1140/epjc/s10052-015-3351-7⟩. ⟨in2p3-01101757⟩
  • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Coherent \psi(2S) photo-production in ultra-peripheral Pb-Pb collisions at \sqrt{s}_{\rm NN} = 2.76 TeV. Physics Letters B, 2015, 751, pp.358-370. ⟨10.1016/j.physletb.2015.10.040⟩. ⟨in2p3-01187258⟩
  • A. Pastore, D. Davesne, J. Navarro. Linear response of homogeneous nuclear matter with energy density functionals. Physics Reports, 2015, 563, pp.1-67. ⟨10.1016/j.physrep.2014.11.002⟩. ⟨in2p3-01108804⟩
  • V. Khachatryan, Y. Amhis, S. Barsuk, M. Borsato, O. Kochebina, et al.. Observation of the rare B0s→μ+μ− decay from the combined analysis of CMS and LHCb data. Nature, 2015, 522 (7554), pp.68-74. ⟨10.1038/nature14474⟩. ⟨in2p3-01084204⟩
  • M. Le Guillou, N. Toulhoat, Y. Pipon, N. Moncoffre, H. Khodja. Deuterium migration in nuclear graphite: Consequences for the behavior of tritium in CO2-cooled reactors and for the decontamination of irradiated graphite waste. Journal of Nuclear Materials, 2015, 461, pp.72-77. ⟨10.1016/j.jnucmat.2015.03.005⟩. ⟨hal-01157259⟩

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