Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • V. Khachatryan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Measurement of the pp to ZZ production cross section and constraints on anomalous triple gauge couplings in four-lepton final states at sqrt(s) = 8 TeV. Physics Letters B, 2015, 740, pp.250-272. ⟨10.1016/j.physletb.2014.11.059⟩. ⟨in2p3-00998918⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for monotop signatures in proton-proton collisions at sqrt(s) = 8 TeV. Physical Review Letters, 2015, 114 (10), pp.101801. ⟨10.1103/PhysRevLett.114.101801⟩. ⟨in2p3-01071978⟩
    • K. Abe, D. Autiero, O. Drapier, J. Dumarchez, S. Emery-Schrenk, et al.. Neutrino Oscillation Physics Potential of the T2K Experiment. Progress of Theoretical Physics, 2015, pp.043C01. ⟨10.1093/ptep/ptv031⟩. ⟨in2p3-01069288⟩
    • K. Abe, J. Adam, H. Aihara, T. Akiri, C. Andreopoulos, et al.. Measurement of the \nu_\mu CCQE cross section on carbon with the ND280 detector at T2K. Physical Review D, 2015, 92, pp.112003. ⟨10.1103/PhysRevD.92.112003⟩. ⟨in2p3-01091410⟩
    • D. Prins, D. Tsimpis. Generalized complex geometry of pure backgrounds in ten and eleven dimensions. Classical and Quantum Gravity, 2015, 32, pp.75004. ⟨10.1088/0264-9381/32/7/075004⟩. ⟨in2p3-01146062⟩
    • Katrin Tanzer, Linda Feketeová, Benjamin Puschnigg, Paul Scheier, Eugen Illenberger, et al.. Reactions in Nitroimidazole and Methylnitroimidazole Triggered by Low-Energy (0–8 eV) Electrons. J.Phys.Chem.A, 2015, 119 (25), pp.6668-6675. ⟨10.1021/acs.jpca.5b02721⟩. ⟨hal-02080733⟩
    • V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Measurement of the forward-backward asymmetry in the production of B^{\pm} mesons in p\bar{p} collisions at \sqrt{s} = 1.96 TeV. Physical Review Letters, 2015, 114 (5), pp.051803. ⟨10.1103/PhysRevLett.114.051803⟩. ⟨in2p3-01082229⟩
    • Hermann Rothard, Gaetano Lanzanò, Benoit Gervais, Enrico de Filippo, Michel Caron, et al.. Swift heavy ion induced electron emission from solids. Journal of Physics: Conference Series, 2015, 629, pp.012007. ⟨10.1088/1742-6596/629/1/012007⟩. ⟨hal-01236320⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for a Higgs boson in the mass range from 145 to 1000 GeV decaying to a pair of W or Z bosons. Journal of High Energy Physics, 2015, 10, pp.144. ⟨10.1007/JHEP10(2015)144⟩. ⟨in2p3-01139758⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Searches for third generation squark production in fully hadronic final states in proton-proton collisions at sqrt(s)=8 TeV. Journal of High Energy Physics, 2015, 1506, pp.116. ⟨10.1007/JHEP06(2015)116⟩. ⟨in2p3-01139106⟩

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