Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the differential cross section for top quark pair production in pp collisions at sqrt(s) = 8 TeV. European Physical Journal C: Particles and Fields, 2015, 75, pp.542. ⟨10.1140/epjc/s10052-015-3709-x⟩. ⟨in2p3-01153175⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for quark contact interactions and extra spatial dimensions using dijet angular distributions in proton-proton collisions at sqrt(s) = 8 TeV. Physics Letters B, 2015, 746, pp.79-99. ⟨10.1016/j.physletb.2015.04.042⟩. ⟨in2p3-01086933⟩
    • V.M. Abazov, M.-C. Cousinou, A. Duperrin, W. Geng, E. Kajfasz, et al.. Measurement of the B_s^0 lifetime in the flavor-specific decay channel B_s^0 \to D_s^- \mu^+\nu X. Physical Review Letters, 2015, 114, pp.062001. ⟨10.1103/PhysRevLett.114.062001⟩. ⟨in2p3-01072258⟩
    • J. Adam, G. Conesa Balbastre, J. Faivre, C. Furget, R. Guernane, et al.. Forward-backward multiplicity correlations in pp collisions at \sqrt{s}=0.9, 2.76 and 7 TeV. Journal of High Energy Physics, 2015, 1505, pp.097. ⟨10.1007/JHEP05(2015)097⟩. ⟨in2p3-01112463⟩
    • D. Barducci, H. Cai, S. de Curtis, F. J. Llanes-Estrada, S. Moretti. Unitarity in composite Higgs approaches with vector resonances. Physical Review D, 2015, 91, pp.095013. ⟨10.1103/PhysRevD.91.095013⟩. ⟨in2p3-01162701⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the Z boson differential cross section in transverse momentum and rapidity in proton-proton collisions at 8 TeV. Physics Letters B, 2015, 749, pp.187-209. ⟨10.1016/j.physletb.2015.07.065⟩. ⟨in2p3-01142339⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for narrow high-mass resonances in proton-proton collisions at sqrt(s) = 8 TeV decaying to Z and Higgs bosons. Physics Letters B, 2015, 748, pp.255-277. ⟨10.1016/j.physletb.2015.07.011⟩. ⟨in2p3-01123804⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the W boson helicity in events with a single reconstructed top quark in pp collisions at sqrt(s)=8 TeV. Journal of High Energy Physics, 2015, 01(2015), pp.053. ⟨10.1007/JHEP01(2015)053⟩. ⟨in2p3-01071982⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for pair-produced resonances decaying to jet pairs in proton-proton collisions at sqrt(s)= 8 TeV. Physics Letters B, 2015, 747, pp.98. ⟨10.1016/j.physletb.2015.04.045⟩. ⟨in2p3-01101705⟩
    • B. Bilki, J. Repond, L. Xia, G. Eigen, M. A. Thomson, et al.. Pion and proton showers in the CALICE scintillator-steel analogue hadron calorimeter. Journal of Instrumentation, 2015, 10, pp.P04014. ⟨10.1088/1748-0221/10/04/P04014⟩. ⟨in2p3-01092573⟩

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