Health

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

SAADE Gaëlle

8786 documents

V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Measurement of the $\phi^*_\eta$ distribution of muon pairs with masses between 30 and 500 GeV in 10.4 fb $^{-1}$ of $p\bar{p}$ collisions. Physical Review D, 2015, 91, pp.072002. ⟨10.1103/PhysRevD.91.072002⟩. ⟨in2p3-01078719⟩
V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Inclusive production of the $X(4140)$ state in $p \overline p$ collisions at D0. Physical Review Letters, 2015, 115, pp.232001. ⟨10.1103/PhysRevLett.115.232001⟩. ⟨in2p3-01188999⟩
V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Simultaneous measurement of forward-backward asymmetry and top polarization in dilepton final states from $t\bar t$ production at the Tevatron. Physical Review D, 2015, 92, pp.052007. ⟨10.1103/PhysRevD.92.052007⟩. ⟨in2p3-01179199⟩
T. Aaltonen, J.-F. Grivaz, T. Guillemin, M. Jaffré, P. Pétroff, et al.. Tevatron combination of single-top-quark cross sections and determination of the magnitude of the Cabibbo-Kobayashi-Maskawa matrix element Vtb. Physical Review Letters, 2015, 115, pp.152003. ⟨10.1103/PhysRevLett.115.152003⟩. ⟨in2p3-01133058⟩
B. Abelev, Laurent Aphecetche, Y.W. Baek, V. Barret, N. Bastid, et al.. Production of $\Sigma(1385)^{\pm}$ and $\Xi(1530)^{0}$ in proton-proton collisions at $\sqrt{s}=$ 7 TeV. European Physical Journal C: Particles and Fields, 2015, 75 (1), pp.1. ⟨10.1140/epjc/s10052-014-3191-x⟩. ⟨in2p3-01005614⟩
N. Arbor, D. Dauvergne, G. Dedes, Jean Michel Létang, K. Parodi, et al.. Monte Carlo comparison of x-ray and proton CT for range calculations of proton therapy beams. Physics in Medicine and Biology, 2015, 60 (19), pp.7585-7599. ⟨10.1088/0031-9155/60/19/7585⟩. ⟨hal-01205940⟩
J. Krimmer, J.-L. Ley, C. Abellan, J.-P. Cachemiche, L. Caponetto, et al.. Development of a Compton camera for medical applications based on silicon strip and scintillation detectors. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2015, 787, pp.98-101. ⟨10.1016/j.nima.2014.11.042⟩. ⟨hal-01101334⟩
L. Luneville, L. Largeau, C. Deranlot, J. Ribis, F. Ott, et al.. Interdiffusion processes at irradiated Cr/Si interfaces. Journal of Alloys and Compounds, 2015, 626, pp.65-69. ⟨10.1016/j.jallcom.2014.11.121⟩. ⟨in2p3-01117636⟩
V.M. Abazov, M.-C. Cousinou, A. Duperrin, W. Geng, E. Kajfasz, et al.. Measurement of the $B_s^0$ lifetime in the flavor-specific decay channel $B_s^0 \to D_s^- \mu^+\nu X$ . Physical Review Letters, 2015, 114, pp.062001. ⟨10.1103/PhysRevLett.114.062001⟩. ⟨in2p3-01072258⟩
V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Search for Violation of $CPT$ and Lorentz invariance in ${B_s^0}$ meson oscillations. Physical Review Letters, 2015, 115, pp.161601. ⟨10.1103/PhysRevLett.115.161601⟩. ⟨in2p3-01163573⟩

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