Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Measurement of the \phi^*_\eta distribution of muon pairs with masses between 30 and 500 GeV in 10.4 fb^{-1} of p\bar{p} collisions. Physical Review D, 2015, 91, pp.072002. ⟨10.1103/PhysRevD.91.072002⟩. ⟨in2p3-01078719⟩
    • J. Krimmer, J.-L. Ley, C. Abellan, J.-P. Cachemiche, L. Caponetto, et al.. Development of a Compton camera for medical applications based on silicon strip and scintillation detectors. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2015, 787, pp.98-101. ⟨10.1016/j.nima.2014.11.042⟩. ⟨hal-01101334⟩
    • Hsi-Ming Chang, M. González-Alonso, J.M. Camalich. Non-standard semileptonic hyperon decays. Physical Review Letters, 2015, 114, pp.161802. ⟨10.1103/PhysRevLett.114.161802⟩. ⟨in2p3-01142863⟩
    • G. Cacciapaglia, A. Deandrea, M. Hashimoto. A scalar hint from the diboson excess?. Physical Review Letters, 2015, 115, pp.171802. ⟨10.1103/PhysRevLett.115.171802⟩. ⟨in2p3-01176887⟩
    • G. Victor, Y. Pipon, N. BĂ©rerd, N. Toulhoat, N. Moncoffre, et al.. Structural modifications induced by ion irradiation and temperature in boron carbide B_4C. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2015, 365, pp.30-34. ⟨10.1016/j.nimb.2015.07.082⟩. ⟨hal-02557849⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for a light charged Higgs boson decaying to c-sbar in pp collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2015, 1512, pp.178. ⟨10.1007/JHEP12(2015)178⟩. ⟨in2p3-01215807⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Performance of the CMS missing transverse energy reconstruction in pp data at sqrt(s) = 8 TeV. Journal of Instrumentation, 2015, 10(2015), pp.P02006. ⟨10.1088/1748-0221/10/02/P02006⟩. ⟨in2p3-01091423⟩
    • S. Chatrchyan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Study of Z production in PbPb and pp collisions at sqrt(s[NN]) = 2.76 TeV in the dimuon and dielectron decay channels. Journal of High Energy Physics, 2015, 03(2015), pp.022. ⟨10.1007/JHEP03(2015)022⟩. ⟨in2p3-01077231⟩
    • V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Simultaneous measurement of forward-backward asymmetry and top polarization in dilepton final states from t\bar t production at the Tevatron. Physical Review D, 2015, 92, pp.052007. ⟨10.1103/PhysRevD.92.052007⟩. ⟨in2p3-01179199⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Production of leading charged particles and leading charged-particle jets at small transverse momenta in pp collisions at sqrt(s)=8 TeV. Physical Review D, 2015, 92, pp.112001. ⟨10.1103/PhysRevD.92.112001⟩. ⟨in2p3-01170638⟩

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