Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • H. Abdoul-Carime, B. Farizon, M. Farizon, J.-C. Mulatier, J.-P. Dutasta, et al.. Solution vs. gas phase relative stability of the choline/acetylcholine cavitand complexes. Physical Chemistry Chemical Physics, 2015, 17, pp.4448-4457. ⟨10.1039/C4CP05354K⟩. ⟨in2p3-01111476⟩
    • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Precision measurement of the mass difference between light nuclei and anti-nuclei. Nature Physics, 2015, 11, pp.811-814. ⟨10.1038/nphys3432⟩. ⟨in2p3-01215032⟩
    • L. Luneville, L. Largeau, C. Deranlot, J. Ribis, F. Ott, et al.. Interdiffusion processes at irradiated Cr/Si interfaces. Journal of Alloys and Compounds, 2015, 626, pp.65-69. ⟨10.1016/j.jallcom.2014.11.121⟩. ⟨in2p3-01117636⟩
    • J. Adam, G. Conesa Balbastre, J. Faivre, C. Furget, R. Guernane, et al.. Measurement of charged jet production cross sections and nuclear modification in p-Pb collisions at \sqrt{s_\rm{NN}} = 5.02 TeV. Physics Letters B, 2015, 749, pp.68-81. ⟨10.1016/j.physletb.2015.07.054⟩. ⟨in2p3-01121987⟩
    • V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Measurement of the forward-backward asymmetry in \Lambda_b^0 and \overline \Lambda_b^0 baryon production in p \overline p collisions at \sqrt s =1.96 TeV. Physical Review D, 2015, 91, pp.072008. ⟨10.1103/PhysRevD.91.072008⟩. ⟨in2p3-01131776⟩
    • L. Feketeová, O. Plekan, M. Goonewardane, M. Ahmed, A. L. Albright, et al.. Photoelectron Spectra and Electronic Structures of the Radiosensitizer Nimorazole and Related Compounds. Journal of Physical Chemistry A, 2015, 119, pp.9986-9995. ⟨10.1021/acs.jpca.5b05950⟩. ⟨in2p3-01237662⟩
    • V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Measurement of the electron charge asymmetry in \boldsymbol{p\bar{p}\rightarrow W+X \rightarrow e\nu +X} decays in \boldsymbol{p\bar{p}} collisions at \boldsymbol{\sqrt{s}=1.96}TeV. Physical Review D, 2015, 91, pp.079901. ⟨10.1103/PhysRevD.91.032007⟩. ⟨in2p3-01093067⟩
    • S. Hohenegger, A. Iqbal, Soo-Jong Rey. M & m Strings and Modular Forms. Physical Review D, 2015, 92, pp.066005. ⟨10.1103/PhysRevD.92.066005⟩. ⟨in2p3-01155686⟩
    • N. Toulhoat, N. Moncoffre, N. Bérerd, Y. Pipon, A. Blondel, et al.. Ion irradiation of 37Cl implanted nuclear graphite: Effect of the energy deposition on the chlorine behavior and consequences for the mobility of 36Cl in irradiated graphite. Journal of Nuclear Materials, 2015, 464, pp.405-410. ⟨10.1016/j.jnucmat.2015.04.010⟩. ⟨in2p3-01198688⟩
    • B. Abelev, G. Conesa Balbastre, J. Faivre, C. Furget, R. Guernane, et al.. Inclusive photon production at forward rapidities in proton-proton collisions at \sqrt{s} = 0.9, 2.76 and 7 TeV. European Physical Journal C: Particles and Fields, 2015, 75, pp.146. ⟨10.1140/epjc/s10052-015-3356-2⟩. ⟨in2p3-01085327⟩

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