Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • J. Krimmer, M. Chevallier, J. Constanzo, D. Dauvergne, M. de Rydt, et al.. Collimated prompt gamma TOF measurements with multi-slit multi-detector configurations. Journal of Instrumentation, 2015, 10, in press. ⟨10.1088/1748-0221/10/01/P01011⟩. ⟨hal-01112176⟩
    • J.-M. Richard, Qian Wang, Qiang Zhao. The lightest neutral hypernuclei with strangeness -1 and -2. Physical Review C, 2015, 91, pp.014003. ⟨10.1103/PhysRevC.91.014003⟩. ⟨in2p3-00978925⟩
    • I. Boucheneb, G. Cacciapaglia, A. Deandrea, B. Fuks. Revisiting monotop production at the LHC. Journal of High Energy Physics, 2015, 2015(01), pp.17. ⟨10.1007/JHEP01(2015)017⟩. ⟨in2p3-01116535⟩
    • B. Abelev, Laurent Aphecetche, A. Baldisseri, V. Barret, N. Bastid, et al.. Charged jet cross sections and properties in proton-proton collisions at \sqrt{s}=7 TeV. Physical Review D, 2015, 91, pp.112012. ⟨10.1103/PhysRevD.91.112012⟩. ⟨in2p3-01180837⟩
    • S.N.T. Majola, D.J. Hartley, L.L. Riedinger, J.F. Sharpey-Schafer, J.M. Allmond, et al.. Observation of γ vibrations and alignments built on non-ground-state configurations in Dy156. Physical Review C, 2015, 91, pp.034330. ⟨10.1103/PhysRevC.91.034330⟩. ⟨in2p3-01146046⟩
    • A. Colliaux, B. Gervais, C. Rodriguez-Lafrasse, M. Beuve. Simulation of ion-induced water radiolysis in different conditions of oxygenation. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2015, 365 (Part B), pp.596-605. ⟨10.1016/j.nimb.2015.08.057⟩. ⟨hal-01214309⟩
    • Hamid Ladjal, Joseph Azencot, Michael Beuve, Philippe Giraud, Jean Michel Moreau, et al.. Biomechanical Modeling of the Respiratory System: Human Diaphragm and Thorax. Springer International Publishing. Computational Biomechanics for Medicine, Part II, Springer International Publishing, pp.101-115, 2015, Computational Biomechanics for Medicine, ⟨10.1007/978-3-319-15503-6_10⟩. ⟨hal-01200840⟩
    • S. Aghion, C. Amsler, A. Ariga, T. Ariga, A.S. Belov, et al.. Positron bunching and electrostatic transport system for the production and emission of dense positronium clouds into vacuum. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2015, 362, pp.86-92. ⟨10.1016/j.nimb.2015.08.097⟩. ⟨in2p3-01258082⟩
    • G. Victor, Y. Pipon, N. Bérerd, N. Toulhoat, N. Moncoffre, et al.. Structural modifications induced by ion irradiation and temperature in boron carbide B_4C. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2015, 365, pp.30-34. ⟨10.1016/j.nimb.2015.07.082⟩. ⟨hal-02557849⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for a light charged Higgs boson decaying to c-sbar in pp collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2015, 1512, pp.178. ⟨10.1007/JHEP12(2015)178⟩. ⟨in2p3-01215807⟩

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