Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Jan Gajewski, Angelo Schiavi, Nils Krah, Gloria Vilches-Freixas, Antoni Rucinski, et al.. Implementation of a Compact Spot-Scanning Proton Therapy System in a GPU Monte Carlo Code to Support Clinical Routine. Front.in Phys., 2020, 8, pp.578605. ⟨10.3389/fphy.2020.578605⟩. ⟨hal-03157090⟩
  • Janina Kopyra, Franck Rabilloud, Hassan Abdoul-Carime. Interaction of Slow Electrons with Thermally Evaporated Manganese(II) Acetylacetonate Complexes. J.Phys.Chem.A, 2020, 124 (11), pp.2186-2192. ⟨10.1021/acs.jpca.9b10119⟩. ⟨hal-02536182⟩
  • Fatmir Asllanaj, Ahmad Addoum. Simultaneous reconstruction of absorption, scattering and anisotropy factor distributions in quantitative photoacoustic tomography. Biomedical Physics & Engineering Express, 2020, 6 (4), pp.045010. ⟨10.1088/2057-1976/ab90a0⟩. ⟨hal-02870842⟩
  • Elisabeth Daguenet, Jonathan Khalifa, Alain Tolédano, Delphine Borchiellini, Yoann Pointreau, et al.. To exploit the 5 ‘R’ of radiobiology and unleash the 3 ‘E’ of immunoediting: ‘RE’-inventing the radiotherapy-immunotherapy combination. Therap.Adv.Med.Oncol., 2020, 12, pp.175883592091344-2. ⟨10.1177/1758835920913445⟩. ⟨hal-02870835⟩
  • Alexandre Arbey, Jérémy Auffinger, Joseph Silk. Evolution of primordial black hole spin due to Hawking radiation. Monthly Notices of the Royal Astronomical Society, 2020, 494 (1), pp.1257-1262. ⟨10.1093/mnras/staa765⟩. ⟨hal-02165581⟩
  • M. Antonello, A. Belov, G. Bonomi, R.S. Brusa, M. Caccia, et al.. Rydberg-positronium velocity and self-ionization studies in a 1T magnetic field and cryogenic environment. Physical Review A, 2020, 102 (1), pp.013101. ⟨10.1103/PhysRevA.102.013101⟩. ⟨hal-02905301⟩
  • K. Bennaceur, J. Dobaczewski, T. Haverinen, M. Kortelainen. Properties of spherical and deformed nuclei using regularized pseudopotentials in nuclear DFT. J.Phys.G, 2020, 47 (10), pp.105101. ⟨10.1088/1361-6471/ab9493⟩. ⟨hal-02542833⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Study of central exclusive \pi^+\pi^- production in proton-proton collisions at \sqrt{s} = 5.02 and 13 TeV. European Physical Journal C: Particles and Fields, 2020, 80 (8), pp.718. ⟨10.1140/epjc/s10052-020-8166-5⟩. ⟨hal-02518095⟩
  • Paulina Stasica, Jakub Baran, Carlos Granja, Nils Krah, Grzegorz Korcyl, et al.. A Simple Approach for Experimental Characterization and Validation of Proton Pencil Beam Profiles. Frontiers in Physics, 2020, 8, pp.346. ⟨10.3389/fphy.2020.00346⟩. ⟨hal-02999622⟩
  • Benjamin P Abbott, Rich Abbott, Thomas D Abbott, Sheelu Abraham, Fausto Acernese, et al.. Model comparison from LIGO–Virgo data on GW170817’s binary components and consequences for the merger remnant. Class.Quant.Grav., 2020, 37 (4), pp.045006. ⟨10.1088/1361-6382/ab5f7c⟩. ⟨hal-02999729⟩

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