Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • B. Abelev, Laurent Aphecetche, Y.W. Baek, V. Barret, N. Bastid, et al.. Production of \Sigma(1385)^{\pm} and \Xi(1530)^{0} in proton-proton collisions at \sqrt{s}= 7 TeV. European Physical Journal C: Particles and Fields, 2015, 75 (1), pp.1. ⟨10.1140/epjc/s10052-014-3191-x⟩. ⟨in2p3-01005614⟩
    • H. Abramowicz, C. Diaconu, D. Hoffmann, E. Sauvan, Corentin Vallée, et al.. Combination of Measurements of Inclusive Deep Inelastic e^{\pm}p Scattering Cross Sections and QCD Analysis of HERA Data. European Physical Journal C: Particles and Fields, 2015, 75, pp.580. ⟨10.1140/epjc/s10052-015-3710-4⟩. ⟨in2p3-01166059⟩
    • T. Aaltonen, J.-F. Grivaz, T. Guillemin, M. Jaffré, P. Pétroff, et al.. Tevatron combination of single-top-quark cross sections and determination of the magnitude of the Cabibbo-Kobayashi-Maskawa matrix element Vtb. Physical Review Letters, 2015, 115, pp.152003. ⟨10.1103/PhysRevLett.115.152003⟩. ⟨in2p3-01133058⟩
    • N. Moncoffre. Vers des matériaux de l'extrême. Demain l'énergie - Paroles de chercheurs, 2015. ⟨in2p3-02013539⟩
    • J. Adam, G. Conesa Balbastre, J. Faivre, C. Furget, R. Guernane, et al.. Measurement of jet suppression in central Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physics Letters B, 2015, 746, pp.1-14. ⟨10.1016/j.physletb.2015.04.039⟩. ⟨in2p3-01114792⟩
    • Kevin Jourde, Dominique Gibert, Jacques Marteau. Improvement of density models of geological structures by fusion of gravity data and cosmic muon radiographies. Geoscientific Instrumentation, Methods and Data Systems, 2015, 4, pp.177-188. ⟨10.5194/gi-4-177-2015⟩. ⟨insu-03579527⟩
    • K. Abe, J. Adam, H. Aihara, C. Andreopoulos, S. Aoki, et al.. Measurement of the \nu_{\mu} charged current quasi-elastic cross-section on carbon with the T2K on-axis neutrino beam. Physical Review D, 2015, 91, pp.112002. ⟨10.1103/PhysRevD.91.112002⟩. ⟨in2p3-01139039⟩
    • K. Abe, J. Adam, H. Aihara, T. Akiri, C. Andreopoulos, et al.. Search for short baseline \nu_e disappearance with the T2K near detector. Physical Review D, 2015, 91, pp.051102. ⟨10.1103/PhysRevD.91.051102⟩. ⟨in2p3-01146091⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the production cross section ratio sigma(chi[2b](1P))/sigma(chi[1b](1P)) in pp collisions at sqrt(s) = 8 TeV. Physics Letters B, 2015, 743, pp.383-402. ⟨10.1016/j.physletb.2015.02.048⟩. ⟨in2p3-01066680⟩
    • V.M. Abazov, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Measurement of the \phi^*_\eta distribution of muon pairs with masses between 30 and 500 GeV in 10.4 fb^{-1} of p\bar{p} collisions. Physical Review D, 2015, 91, pp.072002. ⟨10.1103/PhysRevD.91.072002⟩. ⟨in2p3-01078719⟩

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