Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • D. Lacroix, K. Bennaceur. Semicontact three-body interaction for nuclear density functional theory. Physical Review C, 2015, 91 (1), pp.011302. ⟨10.1103/PhysRevC.91.011302⟩. ⟨in2p3-01141005⟩
    • Hassan Abdoul-Carime, Francis Berthias, Linda Feketeová, Mathieu Marciante, Florent Calvo, et al.. Velocity of a Molecule Evaporated from a Water Nanodroplet: Maxwell-Boltzmann Statistics versus Non-Ergodic Events. Angew.Chem.Int.Ed., 2015, 54 (49), pp.14685-14689. ⟨10.1002/anie.201505890⟩. ⟨hal-03171505⟩
    • A. Pastore, D. Tarpanov, D. Davesne, J. Navarro. Spurious finite-size instabilities in nuclear energy density functionals: spin channel. Physical Review C, 2015, 92, pp.024305. ⟨10.1103/PhysRevC.92.024305⟩. ⟨in2p3-01153566⟩
    • F. Alessio, S. Barsuk, L. Berge, O. A. Bezshyyko, R. S. Boiko, et al.. Proceedings of the third French-Ukrainian workshop on the instrumentation developments for HEP. 2015. ⟨in2p3-01267478⟩
    • G. Aad, S. Albrand, J. Brown, J. Collot, S. Crépé-Renaudin, et al.. Combined Measurement of the Higgs Boson Mass in pp Collisions at \sqrt{s}=7 and 8 TeV with the ATLAS and CMS Experiments. Physical Review Letters, 2015, 114, pp.191803. ⟨10.1103/PhysRevLett.114.191803⟩. ⟨in2p3-01136505⟩
    • K. Abe, J. Adam, H. Aihara, T. Akiri, C. Andreopoulos, et al.. Measurements of neutrino oscillation in appearance and disappearance channels by the T2K experiment with 6.6E20 protons on target. Physical Review D, 2015, 91, pp.072010. ⟨10.1103/PhysRevD.91.072010⟩. ⟨in2p3-01123770⟩
    • Sacha Davidson. Axions: Bose Einstein Condensate or Classical Field?. Astroparticle Physics, 2015, 65, pp.101-107. ⟨10.1016/j.astropartphys.2014.12.007⟩. ⟨in2p3-00995314⟩
    • L. Feketeova, J. Postler, A. Zavras, P. Scheier, S. Denifl, et al.. Decomposition of nitroimidazole ions: experiment and theory . Physical Chemistry Chemical Physics, 2015, 17, pp.12598-12607. ⟨10.1039/C5CP01014D⟩. ⟨in2p3-01159278⟩
    • G. Cacciapaglia, H. Cai, T. Flacke, S.J. Lee, A. Parolini, et al.. Anarchic Yukawas and top partial compositeness: the flavour of a successful marriage. Journal of High Energy Physics, 2015, 1506, pp.085. ⟨10.1007/JHEP06(2015)085⟩. ⟨in2p3-01182771⟩
    • C. Saunders, G. Aldering, P. Antilogus, C. Aragon, S. Bailey, et al.. Type Ia Supernova Distance Modulus Bias and Dispersion from K-correction Errors: A Direct Measurement Using Light Curve Fits to Observed Spectral Time Series. The Astrophysical Journal, 2015, 800 (1), pp.57. ⟨10.1088/0004-637X/800/1/57⟩. ⟨in2p3-01128796⟩

    Powered by HAL logo