Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Study of final-state radiation in decays of Z bosons produced in pp collisions at 7 TeV. Physical Review D, 2015, 91, pp.092012. ⟨10.1103/PhysRevD.91.092012⟩. ⟨in2p3-01126668⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of electroweak production of two jets in association with a Z boson in proton-proton collisions at sqrt(s)= 8 TeV. European Physical Journal C: Particles and Fields, 2015, 75, pp.66. ⟨10.1140/epjc/s10052-014-3232-5⟩. ⟨in2p3-01162744⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for a pseudoscalar boson decaying into a Z boson and the 125 GeV Higgs boson in llbb final states. Physics Letters B, 2015, 748, pp.221-243. ⟨10.1016/j.physletb.2015.07.010⟩. ⟨in2p3-01144115⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for a standard model Higgs boson produced in association with a top-quark pair and decaying to bottom quarks using a matrix element method. European Physical Journal C: Particles and Fields, 2015, 75, pp.251. ⟨10.1140/epjc/s10052-015-3454-1⟩. ⟨in2p3-01142848⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for the production of dark matter in association with top-quark pairs in the single-lepton final state in proton-proton collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2015, 1506, pp.121. ⟨10.1007/JHEP06(2015)121⟩. ⟨in2p3-01141858⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for stealth supersymmetry in events with jets, either photons or leptons, and low missing transverse momentum in pp collisions at 8 TeV. Physics Letters B, 2015, 743, pp.503-525. ⟨10.1016/j.physletb.2015.03.017⟩. ⟨in2p3-01091414⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for long-lived neutral particles decaying to quark-antiquark pairs in proton-proton collisions at sqrt(s) = 8 TeV. Physical Review D, 2015, 91, pp.012007. ⟨10.1103/PhysRevD.91.012007⟩. ⟨in2p3-01091412⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurements of differential and double-differential Drell-Yan cross sections in proton-proton collisions at 8 TeV. European Physical Journal C: Particles and Fields, 2015, 75, pp.147. ⟨10.1140/epjc/s10052-015-3364-2⟩. ⟨in2p3-01091455⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the ratio of the production cross sections times branching fractions of Bc+/- to J/psi pi+/- and B+/- to J/psi K+/- and B(Bc+/- to J/psi pi+/- pi+/- pi-/+)/B(Bc+/- to J/psi pi+/-) in pp collisions at sqrt(s) = 7 TeV. Journal of High Energy Physics, 2015, 01(2015), pp.063. ⟨10.1007/JHEP01(2015)063⟩. ⟨in2p3-01077238⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for physics beyond the standard model in events with two leptons, jets, and missing transverse momentum in pp collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2015, 1504, pp.124. ⟨10.1007/JHEP04(2015)124⟩. ⟨in2p3-01123829⟩

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