Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the inclusive 3-jet production differential cross section in proton-proton collisions at 7 TeV and determination of the strong coupling constant in the TeV range. European Physical Journal C: Particles and Fields, 2015, 75, pp.186. ⟨10.1140/epjc/s10052-015-3376-y⟩. ⟨in2p3-01091445⟩
  • C. Gaillard, Maria Yu Boltoeva, I. Billard, S. Georg, V. Mazan, et al.. Insights into the Mechanism of Extraction of Uranium (VI) from Nitric Acid Solution into an Ionic Liquid by using Tri-n-butyl phosphate. ChemPhysChem, 2015, 16, pp.2653-2662. ⟨10.1002/cphc.201500283⟩. ⟨in2p3-01226378⟩
  • V. Khachatryan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for new resonances decaying via WZ to leptons in proton-proton collisions at sqrt(s)=8 TeV. Physics Letters B, 2015, 740, pp.83-104. ⟨10.1016/j.physletb.2014.11.026⟩. ⟨in2p3-01023624⟩
  • P.-A. Pantel, D. Davesne, Michael Urban. Numerical solution of the Boltzmann equation for trapped Fermi gases with in-medium effects. Physical Review A : Atomic, molecular, and optical physics [1990-2015], 2015, 91 (1), pp.013627. ⟨10.1103/PhysRevA.91.013627⟩. ⟨in2p3-01108812⟩
  • Juan Carlos Munoz-Mateos, Kartik Sheth, Michael Regan, Taehyun Kim, Jarkko Laine, et al.. The Spitzer Survey of Stellar Structure in Galaxies (S4G): Stellar Masses, Sizes and Radial Profiles for 2352 Nearby Galaxies. The Astrophysical Journal Supplement, 2015, 219, pp.3. ⟨10.1088/0067-0049/219/1/3⟩. ⟨in2p3-01158962⟩
  • D. Pomarede, R.B Tully, Y. Hoffman, H.M. Courtois. The Arrowhead Mini-Supercluster of Galaxies. The Astrophysical Journal, 2015, 812, pp.17. ⟨10.1088/0004-637X/812/1/17⟩. ⟨in2p3-01205198⟩
  • G. Aad, S. Albrand, J. Brown, J. Collot, S. Crépé-Renaudin, et al.. Combined Measurement of the Higgs Boson Mass in pp Collisions at \sqrt{s}=7 and 8 TeV with the ATLAS and CMS Experiments. Physical Review Letters, 2015, 114, pp.191803. ⟨10.1103/PhysRevLett.114.191803⟩. ⟨in2p3-01136505⟩
  • J. Billard. Comparing readout strategies to directly detect dark matter. Physical Review D, 2015, 91, pp.023513. ⟨10.1103/PhysRevD.91.023513⟩. ⟨in2p3-01121080⟩
  • D. Lacroix, K. Bennaceur. Semicontact three-body interaction for nuclear density functional theory. Physical Review C, 2015, 91 (1), pp.011302. ⟨10.1103/PhysRevC.91.011302⟩. ⟨in2p3-01141005⟩
  • M. Pinto, M. de Rydt, D. Dauvergne, G. Dedes, N. Freud, et al.. Experimental carbon ion range verification in inhomogeneous phantoms using prompt gammas. Medical Physics, 2015, 42, pp.2342. ⟨10.1118/1.4917225⟩. ⟨hal-01207230⟩

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