Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • D. Davesne, J. W. Holt, A. Pastore, J. Navarro. Effect of three-body forces on response functions in infinite neutron matter. Physical Review C, 2015, 91, pp.014323. ⟨10.1103/PhysRevC.91.014323⟩. ⟨in2p3-01121078⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for physics beyond the standard model in final states with a lepton and missing transverse energy in proton-proton collisions at sqrt(s) = 8 TeV. Physical Review D, 2015, 91, pp.092005. ⟨10.1103/PhysRevD.91.092005⟩. ⟨in2p3-01056276⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Searches for supersymmetry based on events with b jets and four W bosons in pp collisions at 8 TeV. Physics Letters B, 2015, 745, pp.5-28. ⟨10.1016/j.physletb.2015.04.002⟩. ⟨in2p3-01095965⟩
    • S. Chatrchyan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Erratum: Search for new physics in events with same-sign dileptons and jets in pp collisions at sqrt(s)=8 TeV. Journal of High Energy Physics, 2015, 01(2015), pp.014. ⟨10.1007/JHEP01(2015)014⟩. ⟨in2p3-01121082⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Angular analysis of the decay B0 to K*0 mu mu from pp collisions at sqrt(s) = 8 TeV. Physics Letters B, 2015, 753, pp.424-448. ⟨10.1016/j.physletb.2015.12.020⟩. ⟨in2p3-01182739⟩
    • F.C.L. Crespi, A. Bracco, R. Nicolini, E.G. Lanza, A. Vitturi, et al.. 1− and 2+ discrete states in Zr90 populated via the (O17,O′17γ) reaction. Physical Review C, 2015, 91 (2), pp.024323. ⟨10.1103/PhysRevC.91.024323⟩. ⟨in2p3-01137715⟩
    • A. Vogt, B. Birkenbach, P. Reiter, L. Corradi, T. Mijatović, et al.. Light and heavy transfer products in Xe136+U238 multinucleon transfer reactions. Physical Review C, 2015, 92, pp.024619. ⟨10.1103/PhysRevC.92.024619⟩. ⟨in2p3-01198933⟩
    • M. Rigault, G. Aldering, M. Kowalski, Y. Copin, P. Antilogus, et al.. Confirmation of a Star Formation Bias in Type Ia Supernova Distances and its Effect on Measurement of the Hubble Constant. The Astrophysical Journal, 2015, 802, pp.20. ⟨10.1088/0004-637X/802/1/20⟩. ⟨in2p3-01142814⟩
    • Bogna Kubik, Remi Barbier, Alain Castera, Eric Chabanat, Sylvain Ferriol, et al.. Optimization of the multiple sampling and signal extraction in nondestructive exposures. Journal of Astronomical Telescopes Instruments and Systems, 2015, 1 (3), pp.038001. ⟨10.1117/1.JATIS.1.3.038001⟩. ⟨hal-02097411⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Constraints on parton distribution functions and extraction of the strong coupling constant from the inclusive jet cross section in pp collisions at sqrt(s) = 7 TeV. European Physical Journal C: Particles and Fields, 2015, 75, pp.288. ⟨10.1140/epjc/s10052-015-3499-1⟩. ⟨in2p3-01180854⟩

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