Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Alexandre Arbey, Jérémy Auffinger, Joseph Silk. Evolution of primordial black hole spin due to Hawking radiation. Monthly Notices of the Royal Astronomical Society, 2020, 494 (1), pp.1257-1262. ⟨10.1093/mnras/staa765⟩. ⟨hal-02165581⟩
    • C. Amsler, M. Antonello, A. Belov, G. Bonomi, R.S. Brusa, et al.. A cryogenic tracking detector for antihydrogen detection in the AEgIS experiment. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2020, 960, pp.163637. ⟨10.1016/j.nima.2020.163637⟩. ⟨hal-02507897⟩
    • I. Tutusaus, M. Martinelli, V.F. Cardone, S. Camera, S. Yahia-Cherif, et al.. Euclid: The importance of galaxy clustering and weak lensing cross-correlations within the photometric Euclid survey. Astronomy & Astrophysics - A&A, 2020, 643, pp.A70. ⟨10.1051/0004-6361/202038313⟩. ⟨hal-02634687⟩
    • K. Bennaceur, J. Dobaczewski, T. Haverinen, M. Kortelainen. Properties of spherical and deformed nuclei using regularized pseudopotentials in nuclear DFT. Journal of Physics G: Nuclear and Particle Physics, 2020, 47 (10), pp.105101. ⟨10.1088/1361-6471/ab9493⟩. ⟨hal-02542833⟩
    • M. Antonello, A. Belov, G. Bonomi, R.S. Brusa, M. Caccia, et al.. Rydberg-positronium velocity and self-ionization studies in a 1T magnetic field and cryogenic environment. Phys.Rev.A, 2020, 102 (1), pp.013101. ⟨10.1103/PhysRevA.102.013101⟩. ⟨hal-02905301⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for resonant pair production of Higgs bosons in the bbZZ channel in proton-proton collisions at \sqrt{s}= 13 TeV. Phys.Rev.D, 2020, 102 (3), pp.032003. ⟨10.1103/PhysRevD.102.032003⟩. ⟨hal-02886959⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at \sqrt{s} = 13 TeV. JHEP, 2020, 06, pp.146. ⟨10.1007/JHEP06(2020)146⟩. ⟨hal-02431410⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of the \mathrm{t\bar{t}}\mathrm{b\bar{b}} production cross section in the all-jet final state in pp collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2020, 803, pp.135285. ⟨10.1016/j.physletb.2020.135285⟩. ⟨hal-02317339⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for disappearing tracks in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2020, 806, pp.135502. ⟨10.1016/j.physletb.2020.135502⟩. ⟨hal-02557830⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Study of central exclusive \pi^+\pi^- production in proton-proton collisions at \sqrt{s} = 5.02 and 13 TeV. Eur.Phys.J.C, 2020, 80 (8), pp.718. ⟨10.1140/epjc/s10052-020-8166-5⟩. ⟨hal-02518095⟩

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