Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • W. El Kanawati, J.M. Letang, D. Dauvergne, M. Pinto, D. Sarrut, et al.. Monte Carlo simulation of prompt gamma-ray emission in proton therapy using a specific track length estimator. Physics in Medicine and Biology, 2015, 60 (20), pp.8067. ⟨10.1088/0031-9155/60/20/8067⟩. ⟨hal-01207342⟩
  • J. Adam, R. Vernet, A. Baldisseri, H. Borel, J. Castillo Castellanos, et al.. Coherent \rho^0 photoproduction in ultra-peripheral Pb--Pb collisions at \mathbf{\sqrt{\textit{s}_{\rm NN}}} = 2.76 TeV. Journal of High Energy Physics, 2015, 09, pp.095. ⟨10.1007/JHEP09(2015)095⟩. ⟨in2p3-01139191⟩
  • J. Adam, A. Baldisseri, J. Castillo Castellanos, G. Conesa Balbastre, J. Faivre, et al.. Two-pion femtoscopy in p-Pb collisions at \sqrt{s_{\rm NN}}=5.02 TeV. Physical Review C, 2015, 91, pp.034906. ⟨10.1103/PhysRevC.91.034906⟩. ⟨in2p3-01113638⟩
  • Leila Sadr-Arani, Pierre Mignon, Henry Chermette, Hassan Abdoul-Carime, Bernadette Farizon, et al.. Fragmentation mechanisms of cytosine, adenine and guanine ionized bases. Physical Chemistry Chemical Physics, 2015, 11 (17), pp.11813-11826. ⟨10.1039/c5cp00104h⟩. ⟨hal-01187073⟩
  • S. Gavarini, N. Millard-Pinard, V. Garnier, M. Gherrab, J. Baillet, et al.. Elaboration and behavior under extreme irradiation conditions of nano- and micro-structured TiC. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2015, 356-357, pp.114-128. ⟨10.1016/j.nimb.2015.04.064⟩. ⟨in2p3-01182783⟩
  • D. Davesne, J. Navarro, P. Becker, R. Jodon, J. Meyer, et al.. Extended Skyrme pseudo-potential deduced from infinite matter properties. Physical Review C, 2015, 91, pp.064303. ⟨10.1103/PhysRevC.91.064303⟩. ⟨in2p3-01139954⟩
  • A. Pastore, N. Chamel, J. Margueron. Heat capacity of low density neutron matter: from quantum to classical regimes. Monthly Notices of the Royal Astronomical Society, 2015, 448, pp.1887-1892. ⟨10.1093/mnras/stv095⟩. ⟨in2p3-01137677⟩
  • J. Rojo, M. Gouzevitch. The PDF4LHC report on PDFs and LHC data: Results from Run I and preparation for Run II. Journal of Physics G: Nuclear and Particle Physics, 2015, 42, pp.103103. ⟨10.1088/0954-3899/42/10/103103⟩. ⟨in2p3-01179616⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of electroweak production of two jets in association with a Z boson in proton-proton collisions at sqrt(s)= 8 TeV. European Physical Journal C: Particles and Fields, 2015, 75, pp.66. ⟨10.1140/epjc/s10052-014-3232-5⟩. ⟨in2p3-01162744⟩
  • G. Baulieu, M. Bedjidian, K. Belkadhi, J. Berenguer, V. Boudry, et al.. Construction and commissioning of a technological prototype of a high-granularity semi-digital hadronic calorimeter. Journal of Instrumentation, 2015, 10, pp.P10039. ⟨10.1088/1748-0221/10/10/P10039⟩. ⟨in2p3-01164846⟩

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