Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- S. Chatrchyan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of pseudorapidity distributions of charged particles in proton-proton collisions at sqrt(s) = 8 TeV by the CMS and TOTEM experiments. European Physical Journal C: Particles and Fields, 2015, 74, 10, pp.3053. ⟨10.1140/epjc/s10052-014-3053-6⟩. ⟨in2p3-01108890⟩
- V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Angular coefficients of Z bosons produced in pp collisions at 8 TeV and decaying to mu+mu- as a function of transverse momentum and rapidity. Physics Letters B, 2015, 750, pp.154-175. ⟨10.1016/j.physletb.2015.08.061⟩. ⟨in2p3-01142340⟩
- V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Angular analysis of the decay B0 to K*0 mu mu from pp collisions at sqrt(s) = 8 TeV. Physics Letters B, 2015, 753, pp.424-448. ⟨10.1016/j.physletb.2015.12.020⟩. ⟨in2p3-01182739⟩
- V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Constraints on parton distribution functions and extraction of the strong coupling constant from the inclusive jet cross section in pp collisions at sqrt(s) = 7 TeV. European Physical Journal C: Particles and Fields, 2015, 75, pp.288. ⟨10.1140/epjc/s10052-015-3499-1⟩. ⟨in2p3-01180854⟩
- V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Study of vector boson scattering and search for new physics in events with two same-sign leptons and two jets. Physical Review Letters, 2015, 114, pp.051801. ⟨10.1103/PhysRevLett.114.051801⟩. ⟨in2p3-01077206⟩
- D. Prins. Supersymmetric solutions on SU(4)-structure deformed Stenzel space. Physical Review D, 2015, 91, pp.106006. ⟨10.1103/PhysRevD.91.106006⟩. ⟨in2p3-01162740⟩
- S. Kaim, C.M. Petrache, A. Gargano, N. Itaco, T. Zerrouki, et al.. High-spin spectroscopy of Ce139. Physical Review C, 2015, 91, pp.024318. ⟨10.1103/PhysRevC.91.024318⟩. ⟨in2p3-01134757⟩
- J. Kopyra, H. Abdoul-Carime. Temperature dependence of the cross section for the fragmentation of thymine via dissociative electron attachment. The Journal of Chemical Physics, 2015, 142, pp.174303. ⟨10.1063/1.4919638⟩. ⟨in2p3-01155118⟩
- D. Davesne, J. W. Holt, A. Pastore, J. Navarro. Effect of three-body forces on response functions in infinite neutron matter. Physical Review C, 2015, 91, pp.014323. ⟨10.1103/PhysRevC.91.014323⟩. ⟨in2p3-01121078⟩
- H. Balasin, D.N. Blaschke, F. Gieres, M. Schweda. On the energy-momentum tensor in Moyal space. European Physical Journal C: Particles and Fields, 2015, 75, pp.284. ⟨10.1140/epjc/s10052-015-3492-8⟩. ⟨in2p3-01142855⟩
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