Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • X. Artru, I. Chaikovska, R. Chehab, M. Chevallier, O. Dadoun, et al.. A hybrid positron source with a granular converter for CLIC. CLIC Workshop 2015, Jan 2015, Geneve, Switzerland. ⟨in2p3-01112742⟩
  • O. Stézowski. AGATA au CCIN2P3. Réunion 2015 des expériences au Centre de Calcul, Jan 2015, Lyon, France. ⟨in2p3-02101239⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the underlying event activity using charged-particle jets in proton-proton collisions at 2.76 TeV. Journal of High Energy Physics, 2015, 09, pp.137. ⟨10.1007/JHEP09(2015)137⟩. ⟨in2p3-01180715⟩
  • T. Aaltonen, G. Sajot, J. Stark, S. Greder, F. Miconi, et al.. Tevatron Constraints on Models of the Higgs Boson with Exotic Spin and Parity Using Decays to Bottom-Antibottom Quark Pairs. Physical Review Letters, 2015, 114, pp.151802. ⟨10.1103/PhysRevLett.114.151802⟩. ⟨in2p3-01112991⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for "Displaced Supersymmetry" in events with an electron and a muon with large impact parameters. Physical Review Letters, 2015, 114 (6), pp.061801. ⟨10.1103/PhysRevLett.114.061801⟩. ⟨in2p3-01065524⟩
  • V. Khachatryan, S. Baffioni, F. Beaudette, P. Busson, C. Charlot, et al.. Search for new resonances decaying via WZ to leptons in proton-proton collisions at sqrt(s)=8 TeV. Physics Letters B, 2015, 740, pp.83-104. ⟨10.1016/j.physletb.2014.11.026⟩. ⟨in2p3-01023624⟩
  • B. Abelev, Laurent Aphecetche, Guillaume Batigne, C. Cheshkov, B. Cheynis, et al.. K*(892)^0 and PHI(1020) production in Pb-Pb collisions at sqrt(sNN) = 2.76 TeV. Physical Review C, 2015, 91, pp.024609. ⟨10.1103/PhysRevC.91.024609⟩. ⟨in2p3-00971520⟩
  • J. Adam, G. Conesa Balbastre, J. Faivre, C. Furget, R. Guernane, et al.. Measurement of charm and beauty production at central rapidity versus charged-particle multiplicity in proton-proton collisions at \mathbf{\sqrt{{\textit s}}}=7 TeV. Journal of High Energy Physics, 2015, 09, pp.148. ⟨10.1007/JHEP09(2015)148⟩. ⟨in2p3-01148625⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for diphoton resonances in the mass range from 150 to 850 GeV in pp collisions at sqrt(s) = 8 TeV. Physics Letters B, 2015, 750, pp.494-519. ⟨10.1016/j.physletb.2015.09.062⟩. ⟨in2p3-01161723⟩
  • C. Gaillard, Maria Yu Boltoeva, I. Billard, S. Georg, V. Mazan, et al.. Insights into the Mechanism of Extraction of Uranium (VI) from Nitric Acid Solution into an Ionic Liquid by using Tri-n-butyl phosphate. ChemPhysChem, 2015, 16, pp.2653-2662. ⟨10.1002/cphc.201500283⟩. ⟨in2p3-01226378⟩

Powered by HAL logo