Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V. Poda, E. Armengaud, Q. Arnaud, C. Augier, S. Barabash, et al.. Radiopure ZnMoO4 scintillating bolometers for the LUMINEU double-beta experiment. LOW RADIOACTIVITY TECHNIQUES 2015 (LRT 2015): Proceedings of the 5th International Workshop in Low Radioactivity Techniques, Mar 2015, Seattle, United States. pp.040003, ⟨10.1063/1.4927985⟩. ⟨hal-01891564⟩
  • H. Gomez, Christina Cârloganu, Dominique Gibert, Jacques Marteau, Valentin Niess, et al.. Feasibility study of archaeological structures scanning by muon tomography. LOW RADIOACTIVITY TECHNIQUES 2015 (LRT 2015): Proceedings of the 5th International Workshop in Low Radioactivity Techniques, Mar 2015, Seattle, United States. pp.140004 ⟨10.1063/1.4928020⟩. ⟨insu-01310168⟩
  • J. Billard. The neutrino background to direct detection of Dark Matter. Rencontres de Morions - EW Interactions and Unified Theories, Mar 2015, La Thuile, Italy. ⟨in2p3-01141035⟩
  • Abdulhamid Chaikh, Michael Beuve, Jacques Balosso. Nanotechnology in radiation oncology: The need for implantable nano dosimeters for in-vivo real time measurements. International Journal of Cancer Therapy and Oncology, 2015, 3 (2), pp.3217. ⟨10.14319/ijcto.32.17⟩. ⟨hal-01180140⟩
  • Joseph Remillieux, Jean-Michel Moreau, Denis Dauvergne, Jacques Balosso. Les enjeux de l’hadronthérapie par ions carbone. Reflets de la Physique, 2015, 43, pp.26-30. ⟨10.1051/refdp/201543026⟩. ⟨hal-01180095⟩
  • M. Gouzevitch. Plans for PDF measurements at Run II in CMS. Parton Distributions for the LHC, Feb 2015, Benasque, Spain. ⟨hal-02075692⟩
  • M. Gouzevitch. Overview of PDF-sensitive measurements from Run I in CMS. Parton Distributions for the LHC, Feb 2015, Benasque, Spain. ⟨hal-02075695⟩
  • Nadine Redon. Structure of the first excited states in large deformed rare-earth nuclei approaching the proton drip-line. AGATA worshop, Feb 2015, Caen, France. ⟨in2p3-02102160⟩
  • S. Ferrandon, N. Magné, P. Battiston-Montagne, N.-H. Hau-Desbat, O. Diaz, et al.. Cellular and molecular portrait of eleven human glioblastoma cell lines under photon and carbon ion irradiation. Cancer Letters, 2015, 360 (1), pp.10-16. ⟨10.1016/j.canlet.2015.01.025⟩. ⟨hal-01118990⟩
  • Julien Houel, Q.T. Doan, T. Cajgfinger, G. Ledoux, David Amans, et al.. Autocorrelation Analysis for the Unbiased Determination of Power-Law Exponents in Single-Quantum-Dot Blinking. ACS Nano, 2015, 9 (1), pp.886-893. ⟨10.1021/nn506598t⟩. ⟨in2p3-01128805⟩

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