Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Gouzevitch. Experimental Signatures. Higgs Pair Production at Colliders, Apr 2015, Mainz, Germany. ⟨hal-02075701⟩
  • N. Arbor, D. Dauvergne, G. Dedes, Jean Michel Létang, K. Parodi, et al.. Monte Carlo evaluation of X-ray and proton CT for the prediction of the range of proton therapy beams. 3rd ESTRO Forum 2015, Apr 2015, Barcelona, Spain. p87 PD-0139. ⟨hal-01279593⟩
  • S. Mannai, K. Manai, E. Cortina, I. Laktineh. Energy reconstruction in a highly granularity semi-digital hadronic calorimeter for ILC experiments. 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications (ANIMMA 2015), Apr 2015, Lisbon, Portugal. pp.1-7, ⟨10.1109/ANIMMA.2015.7465286⟩. ⟨in2p3-01331153⟩
  • Jochen Krimmer, L. Balleyguier, Denis Dauvergne, Hervé Mathez, Marco Pinto, et al.. Prompt-gamma detection towards absorbed energy monitoring during hadrontherapy. ANIMMA 2015: International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, Apr 2015, Lisboa, Portugal. ⟨hal-02064149⟩
  • D. Autiero. Status and plans of the WA105 Project. 117th meeting of the SPSC committee, Apr 2015, Genève, Switzerland. ⟨in2p3-02108173⟩
  • Gaelle Boudoul. CMS Detector Description for Run II and Beyond. 21st International Conference on Computing in High Energy and Nuclear Physics (CHEP2015), Apr 2015, Okinawa, Japan. ⟨hal-02023400⟩
  • S. Mannai, K. Manai, E. Cortina, I. Laktineh. Energy reconstruction in a highly granularity semi-digital hadronic calorimeter. 21st International Conference on Computing in High Energy and Nuclear Physics (CHEP 2015), Apr 2015, Okinawa, Japan. pp.072033, ⟨10.1088/1742-6596/664/7/072033⟩. ⟨in2p3-01267513⟩
  • G. Boudoul, G. Franzoni, A. Norkus, A. Pol, P. Srimanobhas, et al.. Monte Carlo Production Management at CMS. 21st International Conference on Computing in High Energy and Nuclear Physics, Apr 2015, Okinawa, Japan. pp.072018, ⟨10.1088/1742-6596/664/7/072018⟩. ⟨hal-02016886⟩
  • G. Boudoul. Tracker software for Phase-II CMS. 21st International Conference on Computing in High Energy and Nuclear Physics (CHEP 2015), Apr 2015, Okinawa, Japan. ⟨in2p3-02014297⟩
  • R. Caravita, S. Aghion, C. Amsler, A. Ariga, T. Ariga, et al.. Towards a gravity measurement on cold antimatter atoms. 24th Conference on High Energy Physics (IFAE 2015), Apr 2015, Rome, Italy. pp.237, ⟨10.1393/ncc/i2016-16237-6⟩. ⟨in2p3-01363953⟩

Powered by HAL logo