Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Le Guillou, N. Moncoffre, N. Toulhoat, Y. Pipon, M.-R. Ammar, et al.. Thermal migration of deuterium implanted in graphite: Influence of free surface proximity and structure. 22nd International Conference on Ion Beam Analysis (IBA 2015), Jun 2015, Zagreb, Croatia. pp.307-311, ⟨10.1016/j.nimb.2015.11.034⟩. ⟨in2p3-01295244⟩
  • F. A. Danevich, L. Bergé, R. S. Boiko, M. Chapellier, D. M. Chernyak, et al.. Status of LUMINEU program to search for neutrinoless double beta decay of 100Mo with cryogenic ZnMoO4 scintillating bolometers. Matrix Elements for the Double-beta-decay EXperiments (MEDEX'15), Jun 2015, Prague, Czech Republic. pp.020007, ⟨10.1063/1.4934896⟩. ⟨in2p3-01226305⟩
  • B. Gnoffo, S. Pirrone, G. Politi, M. La Commara, J.P. Wieleczko, et al.. Isospin influence on the decay modes of systems produced in the 78,86Kr+40,48Ca reactions at 10AMeV. EURORIB'15, Jun 2015, Hohenroda, Germany. 2015. ⟨in2p3-01160803⟩
  • Michael Beuve. From water radiolysis to hadrontherapy: NanoxTMa multi-scale model for biological effects. IC-MSQUARE : 4th International Conference on Mathematical Modeling in Physical Sciences, Jun 2015, Mykonos, Greece. ⟨hal-01571051⟩
  • K. Abe, J. Adam, H. Aihara, C. Andreopoulos, S. Aoki, et al.. Measurement of the Electron Neutrino Charged-current Interaction Rate on Water with the T2K ND280 pi-zero Detector. Physical Review D, 2015, 91 (11), pp.112010. ⟨10.1103/PhysRevD.91.112010⟩. ⟨in2p3-01138753⟩
  • J. Adam, G. Conesa Balbastre, J. Faivre, C. Furget, R. Guernane, et al.. Measurement of dijet \mathbf{{\textit{k}}_{T}} in \pPb{} collisions at \mathbf{\sqrt{{\textit{s}}_{NN}}=5.02} TeV. Physics Letters B, 2015, 746, pp.385-395. ⟨10.1016/j.physletb.2015.05.033⟩. ⟨in2p3-01130008⟩
  • J. Adam, Laurent Aphecetche, A. Baldisseri, V. Barret, N. Bastid, et al.. Rapidity and transverse-momentum dependence of the inclusive J/\mathbf{\psi} nuclear modification factor in p-Pb collisions at \mathbf{\sqrt{\textit{s}_{NN}}}=5.02 TeV. Journal of High Energy Physics, 2015, 2015 (6), pp.055. ⟨10.1007/JHEP06(2015)055⟩. ⟨in2p3-01138473⟩
  • Stéphanie Simonet, Marie-Thérèse Aloy, Emma Armandy, Marc Janier, Olivier Tillement, et al.. The Use of Gadolinium-based Nanoparticles to Improve Radiation Therapy Efficacy in HNSCC. 15th International Congress of Radiation Research - ICCR 2015, May 2015, Kyoto, Japan. ⟨hal-01228714⟩
  • Gersende Alphonse, Anne Wozny, Gérald Bertrand, Priscillia Battiston-Montagne, Marion Gilormini, et al.. Overcoming Resistance to Irradiation of Head and Neck Squamous Cell Carcinoma by Targeting the Cancer Stem Cell Subpopulation. 15th International Congress of Radiation Research - ICCR 2015, May 2015, Kyoto, Japan. ⟨hal-01228737⟩
  • Claire Rodriguez-Lafrasse, Coralie Moncharmont, Priscillia Battiston-Montagne, Ghassan Hamdan, Anne Wozny, et al.. Cancer Stem Cells and EMT: Guilty of HNSCC Recurrences but Condemned by the Combination of Carbon Ion Irradiation and EGFR inhibition. 15th International Congress of Radiation Research - ICCR 2015, May 2015, Kyoto, Japan. ⟨hal-01228733⟩

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