Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurement of the Jet Mass Distribution and Top Quark Mass in Hadronic Decays of Boosted Top Quarks in pp Collisions at \sqrt{s} = TeV. Phys.Rev.Lett., 2020, 124 (20), pp.202001. ⟨10.1103/PhysRevLett.124.202001⟩. ⟨hal-02392959⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Study of central exclusive \pi^+\pi^- production in proton-proton collisions at \sqrt{s} = 5.02 and 13 TeV. Eur.Phys.J.C, 2020, 80 (8), pp.718. ⟨10.1140/epjc/s10052-020-8166-5⟩. ⟨hal-02518095⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for resonant pair production of Higgs bosons in the bbZZ channel in proton-proton collisions at \sqrt{s}= 13 TeV. Phys.Rev.D, 2020, 102 (3), pp.032003. ⟨10.1103/PhysRevD.102.032003⟩. ⟨hal-02886959⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for disappearing tracks in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2020, 806, pp.135502. ⟨10.1016/j.physletb.2020.135502⟩. ⟨hal-02557830⟩
  • Paulina Stasica, Jakub Baran, Carlos Granja, Nils Krah, Grzegorz Korcyl, et al.. A Simple Approach for Experimental Characterization and Validation of Proton Pencil Beam Profiles. Frontiers in Physics, 2020, 8, pp.346. ⟨10.3389/fphy.2020.00346⟩. ⟨hal-02999622⟩
  • Jan Gajewski, Angelo Schiavi, Nils Krah, Gloria Vilches-Freixas, Antoni Rucinski, et al.. Implementation of a Compact Spot-Scanning Proton Therapy System in a GPU Monte Carlo Code to Support Clinical Routine. Frontiers in Physics, 2020, 8, pp.578605. ⟨10.3389/fphy.2020.578605⟩. ⟨hal-03157090⟩
  • K. Bennaceur, J. Dobaczewski, T. Haverinen, M. Kortelainen. Properties of spherical and deformed nuclei using regularized pseudopotentials in nuclear DFT. Journal of Physics G: Nuclear and Particle Physics, 2020, 47 (10), pp.105101. ⟨10.1088/1361-6471/ab9493⟩. ⟨hal-02542833⟩
  • Elisabeth Daguenet, Jonathan Khalifa, Alain Tolédano, Delphine Borchiellini, Yoann Pointreau, et al.. To exploit the 5 ‘R’ of radiobiology and unleash the 3 ‘E’ of immunoediting: ‘RE’-inventing the radiotherapy-immunotherapy combination. Therap.Adv.Med.Oncol., 2020, 12, pp.175883592091344-2. ⟨10.1177/1758835920913445⟩. ⟨hal-02870835⟩
  • C. Amsler, M. Antonello, A. Belov, G. Bonomi, R.S. Brusa, et al.. A cryogenic tracking detector for antihydrogen detection in the AEgIS experiment. Nucl.Instrum.Meth.A, 2020, 960, pp.163637. ⟨10.1016/j.nima.2020.163637⟩. ⟨hal-02507897⟩
  • Alexandre Arbey, Jérémy Auffinger, Joseph Silk. Evolution of primordial black hole spin due to Hawking radiation. Monthly Notices of the Royal Astronomical Society, 2020, 494 (1), pp.1257-1262. ⟨10.1093/mnras/staa765⟩. ⟨hal-02165581⟩

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