Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    545 documents

    • Nils Krah, Simon Rit. Optimized conversion from CT numbers to proton relative stopping power based on proton radiography and scatter corrected cone-beam CT images. The Fifteenth International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Jun 2019, Philadelphia, United States. pp.96, ⟨10.1117/12.2534898⟩. ⟨hal-02142832⟩
    • M. Garbacz, G. Battistoni, M. Durante, J. Gajewski, Nils Krah, et al.. Proton Therapy Treatment Plan Verification in CCB Krakow Using Fred Monte Carlo TPS Tool. World Congress on Medical Physics and Biomedical Engineering 2018, pp.783-787, 2019, 978-981-10-9035-6. ⟨10.1007/978-981-10-9035-6_144⟩. ⟨hal-02056752⟩
    • Jessica Garcia, Anne‐sophie Wozny, Florence Geiguer, AurĂ©lia Delherme, David Barthelemy, et al.. Profiling of circulating tumor DNA in plasma of non‐small cell lung cancer patients, monitoring of epidermal growth factor receptor p.T790M mutated allelic fraction using beads, emulsion, amplification, and magnetics companion assay and evaluation in future application in mimicking circulating tumor cells. Cancer Medicine, 2019, 8 (8), pp.3685-3697. ⟨10.1002/cam4.2244⟩. ⟨hal-02311075⟩
    • Ladjohounlou Riad, Alexandra Lauret, Dominique Ardail, Gersende Alphonse, Claire Rodriguez-Lafrasse. RĂŽle des effets non-ciblĂ©s dans la rĂ©ponse des cellules de cancer ORL Ă  la radiothĂ©rapie. FORUM DE LA RECHERCHE EN CANCÉROLOGIE AUVERGNE-RHÔNE-ALPES 2019, Apr 2019, Lyon, France. ⟨hal-02114429⟩
    • Marie-ThĂ©rĂšse Aloy, Jacqueline Sidi Boumedine, G. Ollier, Olivier Tillement, François Lux, et al.. Evaluation de l’effet sensibilisant des nanoparticules AGuIXÂź associĂ©es Ă  une irradiation photonique dans un modĂšle de chondrosarcome. FORUM DE LA RECHERCHE EN CANCÉROLOGIE AUVERGNE-RHÔNE-ALPES 2019, Apr 2019, Lyon, France. ⟨hal-02114329⟩
    • Anne-Sophie Wozny, Guillaume Vares, Gersende Alphonse, Alexandra Lauret, Caterina Monini, et al.. ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion. Cancers, 2019, 11 (4), pp.468. ⟨10.3390/cancers11040468⟩. ⟨hal-02124279⟩
    • Nils Krah, Vincenzo Patera, Simon Rit, Angelo Schiavi, Ilaria Rinaldi. Regularised patient-specific stopping power calibration for proton therapy planning based on proton radiographic images. Physics in Medicine and Biology, 2019, 64, pp.065008. ⟨10.1088/1361-6560/ab03db⟩. ⟨hal-02023861⟩
    • Feriel Khellaf, Nils Krah, Ilaria Rinaldi, Jean-Michel LĂ©tang, Simon Rit. Effects of transverse heterogeneities on the most likely path of protons. Physics in Medicine and Biology, 2019, 64, pp.065003. ⟨10.1088/1361-6560/ab02a8⟩. ⟨hal-02023848⟩
    • Chen-Hui Chan, Floriane Poignant, Michael Beuve, Elise Dumont, David Loffreda. A Water Solvation Shell Can Transform Gold Metastable Nanoparticles in the Fluxional Regime. Journal of Physical Chemistry Letters, 2019, 10, pp.1092-1098. ⟨10.1021/acs.jpclett.8b03822⟩. ⟨hal-02057656⟩
    • Guillaume Landry, Fabian Dörringer, Salim Si-Mohamed, Philippe Douek, Juan F P J Abascal, et al.. Technical Note: Relative proton stopping power estimation from virtual mono-energetic images reconstructed from dual-layer computed tomography. Medical Physics : The international journal of medical physics research and practice, 2019, 46 (4), pp.1821-1828. ⟨10.1002/mp.13404⟩. ⟨hal-02009475⟩

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