Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • X. Artru, I. Chaikovska, R. Chehab, M. Chevallier, O. Dadoun, et al.. Investigations on a hybrid positron source with a granular converter. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2015, 355, p. 60-64. ⟨10.1016/j.nimb.2015.02.027⟩. ⟨in2p3-01072524⟩
  • J.-M. Richard. Exotic hadrons with heavy flavour or hidden flavour. 18th Montpellier International Conference on Quantum Chromodynamics (QCD 15), Jun 2015, Montpellier, France. pp.137-142, ⟨10.1016/j.nuclphysbps.2016.02.029⟩. ⟨in2p3-01314272⟩
  • A. RodrĂ­guez-Sánchez, M. González-Alonso, A. Pich. ChPT parameters from tau-decay data. 18th High-Energy Physics International Conference in Quantum Chromodynamics (QCD 15), Jun 2015, Montpellier, France. pp.108-112, ⟨10.1016/j.nuclphysbps.2016.02.023⟩. ⟨in2p3-01215889⟩
  • A. Melchior, Maria Yu Boltoeva, C. Gaillard, S.I. GrĂ cia-Lanas, M. Tolazzi, et al.. Speciation and structure of the Ni(II)/nitrate system in BumimTf_2N Ionic Liquid. International Symposium on Metal Complexes (ISMEC), Jun 2015, Varsovie, Poland. ⟨in2p3-02094044⟩
  • M. de JĂ©sus. Recent results from the EDELWEISS-III WIMP search experiment. 11th Patras Workshop on Axions, WIMPs and WISPs (Axion-WIMP 2015), Jun 2015, Saragosse, Spain. ⟨hal-02060006⟩
  • Maryvonne de Jesus. EDELWEISS-III: Status and First Data. 11th Patras Workshop on Axions, WIMPs and WISPs, Jun 2015, Zaragoza, Spain. pp.22-25, ⟨10.3204/DESY-PROC-2015-02/maryvonne_dejesus⟩. ⟨hal-02066238⟩
  • W. Zhu, H. Song, L. Yan, W. Zhang, P. Wu, et al.. Tunable flat lens based on microfluidic reconfigurable metasurface. TRANSDUCERS 2015 - 2015 18th International Solid-State Sensors, Actuators and Microsystems Conference, Jun 2015, Anchorage, France. ⟨10.1109/TRANSDUCERS.2015.7181344⟩. ⟨hal-01721164⟩
  • B. Gnoffo, S. Pirrone, G. Politi, M. La Commara, J.P. Wieleczko, et al.. Isospin influence on the decay modes of the systems produced in the 78,86Kr +40,48Ca reactions at 10 AMeV. 12th International Conference on Nucleus-Nucleus Collisions 2015 , Jun 2015, Catania, Italy. pp.08012, ⟨10.1051/epjconf/201611708012⟩. ⟨in2p3-01316703⟩
  • C. Aufranc. Construction DB: logiciel de suivi de construction et de configuration de dĂ©tecteurs. JournĂ©e dispositifs instrumentaux IN2P3, Jun 2015, Paris, France. ⟨in2p3-02101701⟩
  • M. Le Guillou, N. Moncoffre, N. Toulhoat, Y. Pipon, M.-R. Ammar, et al.. Thermal migration of deuterium implanted in graphite: Influence of free surface proximity and structure. 22nd International Conference on Ion Beam Analysis (IBA 2015), Jun 2015, Zagreb, Croatia. ⟨in2p3-02094005⟩

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