Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • F. Berthias, L. Feketeova, M. Marciante, Florent Calvo, V. Forquet, et al.. Collision-induced dissociation of protonated water clusters: Maxwell-Bolztmann statistics versus non-ergodic events. 29th International Conference on Photonic Electronic and Atomic Collisions (ICPEAC 2015), Jul 2015, Toledo, Spain. ⟨in2p3-02086503⟩
  • R.A.J. O'Hair, L. FeketeovĂ , B. Chan, G.N. Khairallah, Vincent Steinmetz, et al.. Linking structure to reactivity for guanine radical cations found in oxidized DNA. The gas-phase model systems 9-methylguanine, deoxyguanosine and the dGdC base pair. 25th Australian and New Zealand Society for Mass Spectrometry (ANZSMS 25) and 6th Asia Oceania Mass Spectrometry Conference (AOMSC 6), Brisbane Convention and Exhibition Centre, Jul 2015, Bribasnne, Australia. ⟨in2p3-02086486⟩
  • D. Lacroix, K. Bennaceur. Nuclear density functional theory with a semi-contact 3-body interaction. International Conference on Nuclear Structure and Related Topics (NSRT15), Jul 2015, Dubna, Russia. pp.02002, ⟨10.1051/epjconf/201610702002⟩. ⟨in2p3-01263099⟩
  • JĂ©rĂ´me Margueron, Rudiney Casali. Empirical equation of state for dense nucleonic matter. 14th Marcel Grossmann Meeting on Recent Developments in Theoretical and Experimental General Relativity, Astrophysics, and Relativistic Field Theories, Jul 2015, Rome, Italy. pp.3392-3395, ⟨10.1142/9789813226609_0436⟩. ⟨hal-01669680⟩
  • A. Uras. Low-mass dimuon measurements in pp, p-Pb and Pb-Pb collisions with ALICE at the LHC. 15th International Conference on Strangeness in Quark Matter (SQM 2015), Jul 2015, Dubna, Russia. pp.012094, ⟨10.1088/1742-6596/668/1/012094⟩. ⟨in2p3-01260163⟩
  • Jacques Marteau, Bruno Carlus, Dominique Gibert, Jean-Christophe Ianigro, Kevin Jourde, et al.. Muon tomography applied to active volcanoes. International Conference on New Photo-detectors,PhotoDet2015, Jul 2015, Moscow, Russia. pp.004, ⟨10.22323/1.252.0004⟩. ⟨in2p3-01217658⟩
  • G. Wang, C. Nones, A. Cazes, M. de Jesus. CUPID: CUORE (Cryogenic Underground Observatory for Rare Events) Upgrade with Particle IDentification. 2015. ⟨in2p3-01170756⟩
  • Gang Wang, C. Nones, A. Cazes, M. De Jesus. R&D towards CUPID (CUORE Upgrade with Particle IDentification). 2015. ⟨in2p3-01170751⟩
  • M. González-Alonso, A. Greljo, G. Isidori, D. Marzocca. Electroweak bounds on Higgs pseudo-observables and

        \[h\rightarrow 4\ell\]

    h → 4 â„“ decays. European Physical Journal C: Particles and Fields, 2015, 75 (7), pp.341. ⟨10.1140/epjc/s10052-015-3555-x⟩. ⟨in2p3-01170747⟩
  • X. Artru, I. Chaikovska, R. Chehab, M. Chevallier, O. Dadoun, et al.. Investigations on a hybrid positron source with a granular converter. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2015, 355, p. 60-64. ⟨10.1016/j.nimb.2015.02.027⟩. ⟨in2p3-01072524⟩

Powered by HAL logo