Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V. Galymov. LBNO-DEMO (WA105): a large demonstrator of the Liquid Argon double-phase TPC. 2015 European Physical Society Conference on High Energy Physics (EPS-HEP 2015), Jul 2015, Vienne, Austria. pp.052. ⟨in2p3-01294378⟩
  • F. Berthias, L. Feketeova, M. Marciante, Florent Calvo, V. Forquet, et al.. Collision-induced dissociation of protonated water clusters: Maxwell-Bolztmann statistics versus non-ergodic events. 29th International Conference on Photonic Electronic and Atomic Collisions (ICPEAC 2015), Jul 2015, Toledo, Spain. ⟨in2p3-02086503⟩
  • D. Contardo. Detector R&D for the HL-LHC upgrade. European Physical Society Conference on High Physics (EPS-HEP), Jul 2015, Vienne, Austria. pp.018. ⟨in2p3-01233998⟩
  • A. Cazes. Recent results from the EDELWEISS-III WIMP search experiment. The European Physical Society Conference on High Energy Physics, Jul 2015, Vienne, Austria. pp.388. ⟨in2p3-01220577⟩
  • M. Farizon. Collision induced dissociation of protonated water clusters: Maxwell-Boltzmann statistics versus non-ergodic events. 29th International Conference on Photonic Electronic and Atomic Collisions (ICPEAC 2015), Jul 2015, Toledo, Spain. ⟨in2p3-02072322⟩
  • J. Kopyra, H. Abdoul-Carime. Dissociative electron attachment to gas phase nucleobases: comparision of thymine and thiothymine. XXIX International Conference on Photonic, Electronic, and Atomic Collisions (ICPEAC2015), Jul 2015, Toledo, Spain. pp.072066, ⟨10.1088/1742-6596/635/7/072066⟩. ⟨in2p3-01372263⟩
  • M. Gouzevitch. Electroweak physics (experimental). European Physical Society Conference on High Physics (EPS-HEP), Jul 2015, Vienne, Austria. pp.006. ⟨in2p3-01234000⟩
  • F. Berthias, L. Feketeova, M. Marciante, Florent Calvo, V. Forquet, et al.. Velocity distributions of a molecule evaporated from mass-selected water nanodroplet. 29th International Conference on Photonic Electronic and Atomic Collisions (ICPEAC 2015), Jul 2015, Toledo, Spain. ⟨in2p3-02086498⟩
  • Linda Feketeova. Electron induced dissociation of biomolecular ions. 29th International Conference on Photonic Electronic and Atomic Collisions (ICPEAC 2015), Jul 2015, Toledo, Spain. ⟨in2p3-02072338⟩
  • F. Berthias, V. Buridon, Linda Feketeová, H. Abdoul-Carime, B. Farizon, et al.. Collision-induced dissociation of protonated water clusters. 29th International Conference on Photonic, Electronic, and Atomic Collisions (ICPEAC), Jul 2015, Toledo, Spain. ⟨in2p3-02086178⟩

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