Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Cacciapaglia, A. Deandrea, N. Gaur, D. Harada, Y. Okada, et al.. Interplay of vector-like top partner multiplets in a realistic mixing set-up. Journal of High Energy Physics, 2015, 2015 (9), pp.12. ⟨10.1007/JHEP09(2015)012⟩. ⟨in2p3-01126697⟩
  • R. Tieulent. ALICE Upgrades: Plans and Potentials. 3rd LHCP conference, Aug 2015, St Petersburg, Russia. ⟨in2p3-01240288⟩
  • Luc Raimbault, Julien Mercadier, M Cuney, N Moncoffre. Halogens in Natural Uranium Dioxide: Determination by SIMS and Preliminary Implications. 13th SGA Biennial Meeting on Mineral Resources in a Sustainable World, Aug 2015, Nancy, France. ⟨in2p3-02094193⟩
  • A. Kellerbauer, S. Aghion, C. Amsler, A. Ariga, T. Ariga, et al.. Probing antimatter gravity – The AEGIS experiment at CERN. 4th International Conference on New Frontiers in Physics, Aug 2015, Chania, Greece. pp.02016, ⟨10.1051/epjconf/201612602016⟩. ⟨in2p3-01394910⟩
  • T. Thuillier, J. Angot, C. BaruĂ©, Pierre Bertrand, J. L. Biarrotte, et al.. Status of the SPIRAL2 injector commissioning. 16th International Conference on Ion Sources (ICIS 2015), Aug 2015, New York City, United States. pp.02A733, ⟨10.1063/1.4935227⟩. ⟨in2p3-01189013⟩
  • Abdulhamid Chaikh, Micaela Cunha, Etienne Testa, Michael Beuve, Jacques Balosso. Characterization of nanodosimeter for real time measurements in radiotherapy and medical physics. Nanotechnology Congress & Expo, Aug 2015, Frankfurt, Germany. pp.47, ⟨10.4172/2157-7439.S1.021⟩. ⟨hal-01235989⟩
  • B. Serra, A. Secroun, J.-C. ClĂ©mens, P. Lagier, M. Niclas, et al.. Characterization of Euclid-like H2RG IR detectors for the NISP instrument. UV/Optical/IR Space Telescopes and Instruments: Innovative Technologies and Concepts VII, Aug 2015, San Diego, California, United States. ⟨10.1117/12.2188439⟩. ⟨in2p3-01199017⟩
  • J.C. ClĂ©mens, B. Serra, M. Niclas, A. Ealet, W. Gillard, et al.. EUCLID detector system demonstrator model: a first demonstration of the NISP detection system. UV, X-Ray, and Gamma-Ray Space Instrumentation for Astronomy XIX, Aug 2015, San Diego, United States. pp.96020Y, ⟨10.1117/12.2188581⟩. ⟨hal-02144339⟩
  • L. Feketeová, G.-N. Khairallah, R.A.J. O'Hair, S.B. Nielsen. Gas-phase fragmentation of deprotonated tryptophan and its clusters [Trp(n)-H](-) induced by different activation methods. Rapid Communications in Mass Spectrometry, 2015, 29 (15), pp.1-8. ⟨10.1002/rcm.7233⟩. ⟨in2p3-01179614⟩
  • B. Courbon. Young Scientist Forum: Observation and properties of a Higgs Boson in the Two-Photon Decay Channel with CMS. HH2015: Higgs Hunting 2015, Jul 2015, Orsay, France. ⟨hal-02070572⟩

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