Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • E. Armengaud, Q. Arnaud, C. Augier, A. Benoît, L Bergé S Boiko, et al.. LUMINEU: a search for neutrinoless double beta decay based on ZnMoO4 scintillating bolometers. 14th International Conference on Topics in Astroparticle and Underground Physics, University of Torino; INFN, Sep 2015, Torino, Italy. pp.062008, ⟨10.1088/1742-6596/718/6/062008⟩. ⟨hal-03722374⟩
  • H Gómez, C Carloganu, Dominique Gibert, J Jacquemier, Y Karyotakis, et al.. Studies on muon tomography for archaeological internal structures scanning. XIV International Conference on Topics in Astroparticle and Underground Physics (TAUP 2015), Sep 2015, Torino, Italy. pp.052016, ⟨10.1088/1742-6596/718/5/052016⟩. ⟨insu-01330742⟩
  • V.G. Nguyen, A.P. Severyukhin, J. Margueron, A.N. Borzov. Effects of nucleon effective mass on nuclear beta-decay rates . XXI International School on Nuclear Physics, Neutron Physics and Applications, Sep 2015, Varna, Bulgaria. ⟨in2p3-01348537⟩
  • X. Artru, C. Ray. Common characteristics of synchrotron radiation and light leaking from a bent optical fiber. XI International Symposium on Radiation from Relativistic Electrons in Periodic Structures (RREPS2015), Sep 2015, Saint-Petersbourg, Russia. pp.012008, ⟨10.1088/1742-6596/732/1/012008⟩. ⟨in2p3-01360646⟩
  • X. Artru, C. Ray. Coherent Light induced in Optical Fiber by a Charged Particle. XI International Symposium on Radiation from Relativistic Electrons in Periodic Structures (RREPS2015), Sep 2015, Saint-Petersbourg, Russia. pp.012005, ⟨10.1088/1742-6596/732/1/012005⟩. ⟨in2p3-01360638⟩
  • X. Artru, I. Chaikovska, R. Chehab, M. Chevallier, O. Dadoun, et al.. Investigations on a Reliable Positron Source for ILC and CLIC with the Hybrid Target. POSIPOL 2015 International Positron Source Workshop, Sep 2015, Cockcroft, United Kingdom. ⟨in2p3-01194881⟩
  • Sacha Davidson, M.L. Mangano, S. Perries, V. Sordini. Lepton flavour violating top decays at the LHC. European Physical Journal C: Particles and Fields, 2015, 75 (9), pp.450. ⟨10.1140/epjc/s10052-015-3649-5⟩. ⟨in2p3-01180713⟩
  • D. Prins, D. Tsimpis. 3d

        \[\mathcal{N}=1\]

    effective supergravity and F-theory from M-theory on fourfolds. Journal of High Energy Physics, 2015, 2015 (9), pp.107. ⟨10.1007/JHEP09(2015)107⟩. ⟨in2p3-01174043⟩
  • H. Abramowicz, V. Brisson, M. Jacquet, Zhiqing Zhang, F. Zomer, et al.. Combination of Differential D^{*\pm} Cross-Section Measurements in Deep-Inelastic ep Scattering at HERA. Journal of High Energy Physics, 2015, 149, ⟨10.1007/JHEP09(2015)149⟩. ⟨in2p3-01134452⟩
  • G. Cacciapaglia, M.T. Frandsen. Unitarity implications of a diboson resonance in the TeV region for Higgs physics. Physical Review D, 2015, 92 (5), pp.055035. ⟨10.1103/PhysRevD.92.055035⟩. ⟨in2p3-01183080⟩

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