Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Edouard Bechetoille, Hervé Mathez. Double Slope Dynamic Range and Low Noise Charge Sensitive Amplifier. NSS-MIC_2015, Nov 2015, San Diego, United States. ⟨in2p3-01267327⟩
    • I. Laktineh. New Semi-Digital Hadronic Calorimeter R&D for the Future ILC Experiments. 2015 IEEE Nuclear Science Symposium, Oct 2015, San Diego, United States. ⟨in2p3-02092553⟩
    • Clement Stahl, J. Leske, C. Bauer, D. Bazzacco, E. Farnea, et al.. Population of the 2(ms)(+) mixed-symmetry state of Ba-140 with the alpha-transfer reaction. Physical Review C, 2015, 92 (issue 4), pp.044324. ⟨10.1103/PhysRevC.92.044324⟩. ⟨in2p3-01232789⟩
    • D. Tsimpis. The action principle and the supersymmetrisation of Chern-Simons terms in eleven-dimensional supergravity. Supergravity at 40 Galileo Galilei Institute for Theoretical Physics, Oct 2015, Florence, Italy. ⟨hal-02063779⟩
    • Jean-Baptiste Flament. Phenomenology of the scalar sector beyond the standard model. Physics [physics]. Université Claude Bernard - Lyon I, 2015. English. ⟨NNT : 2015LYO10178⟩. ⟨tel-01367530⟩
    • Jose David Ruiz-Alvarez. Search for a vector-like quark T' decaying into top+Higgs in single production mode in full hadronic final state using CMS data collected at 8 TeV . High Energy Physics - Experiment [hep-ex]. Université Claude Bernard Lyon 1, 2015. English. ⟨NNT : ⟩. ⟨tel-01328175⟩
    • B. Birkenbach, A. Vogt, K. Geibel, F. Recchia, P. Reiter, et al.. Spectroscopy of the neutron-rich actinide nucleus U-240 following multinucleon-transfer reactions. Physical Review C, 2015, 92 (issue 4), pp.044319. ⟨10.1103/PhysRevC.92.044319⟩. ⟨in2p3-01232843⟩
    • S. Pirrone, G. Politi, J.P. Wieleczko, E. De Filippo, B. Gnoffo, et al.. Isospin influence on the decay modes of compound systems produced in the ^{78,86}Kr + ^{40,48}Ca at 10 AMeV. CNR*15 - 5th International Workshop on Compound-Nuclear Reactions and Related Topics, Oct 2015, Tokyo, Japan. pp.13001, ⟨10.1051/epjconf/201612213001⟩. ⟨in2p3-01357772⟩
    • D.V. Poda, L. Bergé, R.S. Boiko, M. Chapellier, D.M. Chernyak, et al.. Molybdenum containing scintillating bolometers for double-beta decay search (LUMINEU program). 3rd French-Ukrainian workshop on the instrumentation developments for HEP, Oct 2015, Orsay, France. ⟨in2p3-01333292⟩
    • E. Khan, J. Margueron, F. Gulminelli, Ad. R. Raduta. Microscopic evaluation of the hypernuclear chart with \Lambda hyperons. Physical Review C, 2015, 92 (4), pp.044313. ⟨10.1103/PhysRevC.92.044313⟩. ⟨in2p3-01158954⟩

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