Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • F. Dias, S. Gadatsch, M. Gouzevich, C. Leonidopoulos, S. Novaes, et al.. Combination of Run-1 Exotic Searches in Diboson Final States at the LHC. Journal of High Energy Physics, 2016, 04, pp.155. ⟨10.1007/JHEP04(2016)155⟩. ⟨in2p3-01267440⟩
  • Teng Ma, G. Cacciapaglia. Fundamental Composite 2HDM: SU(N) with 4 flavours. Journal of High Energy Physics, 2016, 03, pp.211. ⟨10.1007/JHEP03(2016)211⟩. ⟨in2p3-01193148⟩
  • Julien Smeets, Frauke Roellinghoff, Guillaume Janssens, Irene Perali, Andrea Celani, et al.. experimental comparison of Knife-edge and Multi-Parallel slit collimators for Prompt gamma imaging of Proton Pencil Beams. Frontiers in Oncology, 2016, 6, pp.156. ⟨10.3389/fonc.2016.00156⟩. ⟨hal-01457574⟩
  • M. Pinto, Denis Dauvergne, Nicolas Freud, Jochen Krimmer, Jean Michel LĂ©tang, et al.. Assessment of Geant4 Prompt-Gamma Emission Yields in the Context of Proton Therapy Monitoring. Frontiers in Oncology, 2016, 6 (10), ⟨10.3389/fonc.2016.00010⟩. ⟨hal-01272829⟩
  • B. MĂ©ry, A. Vallard, S. Espenel, N. Badie, M. Thiermant, et al.. Cancer de prostate des sujets âgĂ©s : place et rĂ´le de l’évaluation gĂ©riatrique. Progrès en Urologie, 2016, 26 (9), pp.524 - 531. ⟨10.1016/j.purol.2016.07.002⟩. ⟨hal-01376268⟩
  • Voichita Maxim, Xavier Lojacono, Estelle Hilaire, Jochen Krimmer, Etienne Testa, et al.. Probabilistic models and numerical calculation of system matrix and sensitivity in list-mode MLEM 3D reconstruction of Compton camera images. Physics in Medicine and Biology, 2016, 61 (1), pp.243-264. ⟨10.1088/0031-9155/61/1/243⟩. ⟨hal-01272780⟩
  • A. Melchior, C. Gaillard, S. GrĂ cia Lanas, M. Tolazzi, I. Billard, et al.. Nickel(II) Complexation with Nitrate in Dry [C4mim][Tf2N] Ionic Liquid: A Spectroscopic, Microcalorimetric, and Molecular Dynamics Study. Inorganic Chemistry, 2016, 55, pp.3498-3507. ⟨10.1021/acs.inorgchem.5b02937⟩. ⟨in2p3-01319195⟩
  • J. Adam, R. Vernet, I. Belikov, J.C. Hamon, B. Hippolyte, et al.. Pseudorapidity dependence of the anisotropic flow of charged particles in Pb-Pb collisions at \sqrt{s_{\rm NN}}=2.76 TeV. Physics Letters B, 2016, 762, pp.376-388. ⟨10.1016/j.physletb.2016.07.017⟩. ⟨in2p3-01313110⟩
  • J. Adam, Laurent Aphecetche, B. Audurier, I. Belikov, H. Borel, et al.. Measurement of transverse energy at midrapidity in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physical Review C, 2016, 94, pp.034903 ⟨10.1103/PhysRevC.94.034903⟩. ⟨in2p3-01289036⟩
  • F. Picollo, S. Rubanov, C. Tomba, A. Battiato, E. Enrico, et al.. Effects of high-power laser irradiation on sub-superficial graphitic layers in single-crystal diamond. Acta Materialia, 2016, 103, pp.665-671. ⟨10.1016/j.actamat.2015.10.046⟩. ⟨in2p3-01270645⟩

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