Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • N. Abgrall, J. Dumarchez, M. Pavin, B. A. Popov, A. Robert, et al.. Measurements of \pi^{\pm} differential yields from the surface of the T2K replica target for incoming 31 GeV/c protons with the NA61/SHINE spectrometer at the CERN SPS. European Physical Journal C: Particles and Fields, 2016, 76, pp.617. ⟨10.1140/epjc/s10052-016-4440-y⟩. ⟨in2p3-01299022⟩
  • N.H. Tan, D.T. Loan, D.T. Khoa, J. Margueron. Mean-field study of hot beta-stable protoneutron star matter: Impact of the symmetry energy and nucleon effective mass. Physical Review C, 2016, 93, pp.035806. ⟨10.1103/PhysRevC.93.035806⟩. ⟨in2p3-01300484⟩
  • N. Lesparre, A. Boyle, B. Grychtol, Justo Cabrera, J. Marteau, et al.. Electrical resistivity imaging in transmission between surface and underground tunnel for fault characterization. Journal of Applied Geophysics, 2016, 128, pp.163-178. ⟨10.1016/j.jappgeo.2016.03.004⟩. ⟨in2p3-01323483⟩
  • K. Abe, O. Drapier, M. Gonin, Th.A. Mueller, B. Quilain, et al.. Upper bound on neutrino mass based on T2K neutrino timing measurements. Physical Review D, 2016, 93, pp.012006. ⟨10.1103/PhysRevD.93.012006⟩. ⟨in2p3-01123834⟩
  • K. HadyĹ„ska-KlČ©k, M. ZieliĹ„ska, J. Chavas, L. Charles, P. DĂ©sesquelles, et al.. Superdeformed and Triaxial States in ^{42}Ca. Physical Review Letters, 2016, 117, pp.062501. ⟨10.1103/PhysRevLett.117.062501⟩. ⟨in2p3-01358320⟩
  • F. Dias, S. Gadatsch, M. Gouzevich, C. Leonidopoulos, S. Novaes, et al.. Combination of Run-1 Exotic Searches in Diboson Final States at the LHC. Journal of High Energy Physics, 2016, 04, pp.155. ⟨10.1007/JHEP04(2016)155⟩. ⟨in2p3-01267440⟩
  • Teng Ma, G. Cacciapaglia. Fundamental Composite 2HDM: SU(N) with 4 flavours. Journal of High Energy Physics, 2016, 03, pp.211. ⟨10.1007/JHEP03(2016)211⟩. ⟨in2p3-01193148⟩
  • B. MĂ©ry, A. Vallard, S. Espenel, N. Badie, M. Thiermant, et al.. Cancer de prostate des sujets âgĂ©s : place et rĂ´le de l’évaluation gĂ©riatrique. Progrès en Urologie, 2016, 26 (9), pp.524 - 531. ⟨10.1016/j.purol.2016.07.002⟩. ⟨hal-01376268⟩
  • Julien Smeets, Frauke Roellinghoff, Guillaume Janssens, Irene Perali, Andrea Celani, et al.. experimental comparison of Knife-edge and Multi-Parallel slit collimators for Prompt gamma imaging of Proton Pencil Beams. Frontiers in Oncology, 2016, 6, pp.156. ⟨10.3389/fonc.2016.00156⟩. ⟨hal-01457574⟩
  • M. Pinto, Denis Dauvergne, Nicolas Freud, Jochen Krimmer, Jean Michel LĂ©tang, et al.. Assessment of Geant4 Prompt-Gamma Emission Yields in the Context of Proton Therapy Monitoring. Frontiers in Oncology, 2016, 6 (10), ⟨10.3389/fonc.2016.00010⟩. ⟨hal-01272829⟩

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