Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • K. Abe, C. Andreopoulos, M. Antonova, S. Aoki, A. Ariga, et al.. Measurement of the muon neutrino inclusive charged-current cross section in the energy range of 1-3 GeV with the T2K INGRID detector. Physical Review D, 2016, 93, pp.072002. ⟨10.1103/PhysRevD.93.072002⟩. ⟨in2p3-01204505⟩
    • J. Adam, Laurent Aphecetche, B. Audurier, I. Belikov, H. Borel, et al.. Measurement of transverse energy at midrapidity in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physical Review C, 2016, 94, pp.034903 ⟨10.1103/PhysRevC.94.034903⟩. ⟨in2p3-01289036⟩
    • N. Abgrall, J. Dumarchez, M. Pavin, B. A. Popov, A. Robert, et al.. Measurements of \pi^{\pm} differential yields from the surface of the T2K replica target for incoming 31 GeV/c protons with the NA61/SHINE spectrometer at the CERN SPS. European Physical Journal C: Particles and Fields, 2016, 76, pp.617. ⟨10.1140/epjc/s10052-016-4440-y⟩. ⟨in2p3-01299022⟩
    • N.H. Tan, D.T. Loan, D.T. Khoa, J. Margueron. Mean-field study of hot beta-stable protoneutron star matter: Impact of the symmetry energy and nucleon effective mass. Physical Review C, 2016, 93, pp.035806. ⟨10.1103/PhysRevC.93.035806⟩. ⟨in2p3-01300484⟩
    • Clotilde Gaillard, Maria Yu Boltoeva, Isabelle Billard, Sylvia Georg, ValĂ©rie Mazan, et al.. Ionic liquid-based uranium( vi ) extraction with malonamide extractant: cation exchange vs. neutral extraction. RSC Advances, 2016, 6 (74), pp.70141-70151. ⟨10.1039/c6ra11345a⟩. ⟨hal-02271345⟩
    • F. Picollo, S. Rubanov, C. Tomba, A. Battiato, E. Enrico, et al.. Effects of high-power laser irradiation on sub-superficial graphitic layers in single-crystal diamond. Acta Materialia, 2016, 103, pp.665-671. ⟨10.1016/j.actamat.2015.10.046⟩. ⟨in2p3-01270645⟩
    • K. HadyĹ„ska-KlČ©k, M. ZieliĹ„ska, J. Chavas, L. Charles, P. DĂ©sesquelles, et al.. Superdeformed and Triaxial States in ^{42}Ca. Physical Review Letters, 2016, 117, pp.062501. ⟨10.1103/PhysRevLett.117.062501⟩. ⟨in2p3-01358320⟩
    • J. Adam, R. Vernet, I. Belikov, J.C. Hamon, B. Hippolyte, et al.. Pseudorapidity dependence of the anisotropic flow of charged particles in Pb-Pb collisions at \sqrt{s_{\rm NN}}=2.76 TeV. Physics Letters B, 2016, 762, pp.376-388. ⟨10.1016/j.physletb.2016.07.017⟩. ⟨in2p3-01313110⟩
    • B. MĂ©ry, A. Vallard, S. Espenel, N. Badie, M. Thiermant, et al.. Cancer de prostate des sujets âgĂ©s : place et rĂ´le de l’évaluation gĂ©riatrique. Progrès en Urologie, 2016, 26 (9), pp.524 - 531. ⟨10.1016/j.purol.2016.07.002⟩. ⟨hal-01376268⟩
    • Julien Smeets, Frauke Roellinghoff, Guillaume Janssens, Irene Perali, Andrea Celani, et al.. experimental comparison of Knife-edge and Multi-Parallel slit collimators for Prompt gamma imaging of Proton Pencil Beams. Frontiers in Oncology, 2016, 6, pp.156. ⟨10.3389/fonc.2016.00156⟩. ⟨hal-01457574⟩

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