Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. Melchior, C. Gaillard, S. GrĂ cia Lanas, M. Tolazzi, I. Billard, et al.. Nickel(II) Complexation with Nitrate in Dry [C4mim][Tf2N] Ionic Liquid: A Spectroscopic, Microcalorimetric, and Molecular Dynamics Study. Inorganic Chemistry, 2016, 55, pp.3498-3507. ⟨10.1021/acs.inorgchem.5b02937⟩. ⟨in2p3-01319195⟩
  • J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. Charge-dependent flow and the search for the Chiral Magnetic Wave in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physical Review C, 2016, 93, pp.044903. ⟨10.1103/PhysRevC.93.044903⟩. ⟨in2p3-01246099⟩
  • J. Adam, I. Belikov, J.C. Hamon, B. Hippolyte, C. Kuhn, et al.. Centrality dependence of the charged-particle multiplicity density at mid-rapidity in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 5.02 TeV. Physical Review Letters, 2016, 116, pp.222302 ⟨10.1103/PhysRevLett.116.222302⟩. ⟨in2p3-01247070⟩
  • F. Picollo, S. Rubanov, C. Tomba, A. Battiato, E. Enrico, et al.. Effects of high-power laser irradiation on sub-superficial graphitic layers in single-crystal diamond. Acta Materialia, 2016, 103, pp.665-671. ⟨10.1016/j.actamat.2015.10.046⟩. ⟨in2p3-01270645⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. A search for pair production of new light bosons decaying into muons. Physics Letters B, 2016, 752, pp.146-168. ⟨10.1016/j.physletb.2015.10.067⟩. ⟨in2p3-01158778⟩
  • W. Adam, T. Bergauer, M. Dragicevic, M. Friedl, R. Fruehwirth, et al.. Trapping in irradiated p-on-n silicon sensors at fluences anticipated at the HL-LHC outer tracker. Journal of Instrumentation, 2016, 11, pp.P04023. ⟨10.1088/1748-0221/11/04/P04023⟩. ⟨in2p3-01326320⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the top quark mass using charged particles in collisions at sqrt(s) = 8 TeV. Physical Review D, 2016, 93, pp.092006. ⟨10.1103/PhysRevD.93.092006⟩. ⟨in2p3-01291738⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for R-parity violating decays of a top squark in proton-proton collisions at sqrt(s) = 8 TeV. Physics Letters B, 2016, 760, pp.178-201. ⟨10.1016/j.physletb.2016.06.039⟩. ⟨in2p3-01274542⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Study of B Meson Production in p+Pb Collisions at root s(NN)=5.02  TeV Using Exclusive Hadronic Decays. Physical Review Letters, 2016, 116, pp. 032301 ⟨10.1103/PhysRevLett.116.032301⟩. ⟨in2p3-01187903⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the integrated and differential t-tbar production cross sections for high-pt top quarks in pp collisions at sqrt(s) = 8 TeV. Physical Review D, 2016, 94, pp.072002. ⟨10.1103/PhysRevD.94.072002⟩. ⟨in2p3-01310733⟩

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