Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Forward-backward asymmetry of Drell-Yan lepton pairs in pp collisions at sqrt(s) = 8 TeV. European Physical Journal C: Particles and Fields, 2016, 76, pp.325. ⟨10.1140/epjc/s10052-016-4156-z⟩. ⟨in2p3-01259158⟩
  • K. Abe, D. Autiero, A. Blondel, V. Galymov, J. Marteau, et al.. Measurement of double-differential muon neutrino charged-current interactions on C_8H_8 without pions in the final state using the T2K off-axis beam. Physical Review D, 2016, 93, pp.112012. ⟨10.1103/PhysRevD.93.112012⟩. ⟨in2p3-01274151⟩
  • T. Price, N. K. Watson, J. S. Marshall, M. A. Thomson, D. R. Ward, et al.. Hadron shower decomposition in the highly granular CALICE analogue hadron calorimeter. Journal of Instrumentation, 2016, 11, pp.P06013. ⟨10.1088/1748-0221/11/06/P06013⟩. ⟨in2p3-01281362⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of inclusive jet production and nuclear modifications in pPb collisions at sqrt(s[NN]) = 5.02 TeV. European Physical Journal C: Particles and Fields, 2016, 76, pp.372. ⟨10.1140/epjc/s10052-016-4205-7⟩. ⟨in2p3-01253541⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the inclusive jet cross section in pp collisions at sqrt(s) = 2.76 TeV. European Physical Journal C: Particles and Fields, 2016, 76, pp.265. ⟨10.1140/epjc/s10052-016-4083-z⟩. ⟨in2p3-01247439⟩
  • Z. Deng, Y. Li, Y. Wang, Q. Yue, Z. Yang, et al.. Resistive Plate Chamber Digitization in a Hadronic Shower Environment. Journal of Instrumentation, 2016, 11, pp.P06014 ⟨10.1088/1748-0221/11/06/P06014⟩. ⟨in2p3-01303455⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for long-lived charged particles in proton-proton collisions at sqrt(s) = 13 TeV. Physical Review D, 2016, 94, pp.112004 ⟨10.1103/PhysRevD.94.112004⟩. ⟨in2p3-01372972⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the Z gamma to nu nu-bar gamma production cross section in pp collisions at sqrt(s) = 8 TeV and limits on anomalous Z-Z-gamma and Z-gamma-gamma trilinear gauge boson couplings. Physics Letters B, 2016, 760, pp.448-468. ⟨10.1016/j.physletb.2016.06.080⟩. ⟨in2p3-01278250⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for exotic decays of a Higgs boson into undetectable particles and photons. Physics Letters B, 2016, 753, pp.363-388. ⟨10.1016/j.physletb.2015.12.017⟩. ⟨in2p3-01171155⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for neutral MSSM Higgs bosons decaying to \mu^{+} \mu^{-} in pp collisions at \sqrt{s} = 7 and 8 TeV. Physics Letters B, 2016, 752, pp.221-246. ⟨10.1016/j.physletb.2015.11.042⟩. ⟨in2p3-01186123⟩

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